Suhuang antitussive capsule inhibits NLRP3 inflammasome activation and ameliorates pulmonary dysfunction via suppression of endoplasmic reticulum stress in cough variant asthma.

Qin, Weiwei; Wu, Xingdong; Jia, Yuning; Tong, Xiyang; Guo, Chao; Chen, Dong; Wang, Zhen; Tan, Ninghua

Qin, Weiwei; Wu, Xingdong; Jia, Yuning; Tong, Xiyang; Guo, Chao; Chen, Dong; Wang, Zhen; Tan, Ninghua.

Afiliação

Qin W; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.
Wu X; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.
Jia Y; Yangtze River Pharmaceutical Group Beijing Haiyan Pharmaceutical Co., Ltd., Beijing 102206, PR China; Beijing University of Chemical Technology, Beijing 100029, PR China.
Tong X; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.
Guo C; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China.
Chen D; Yangtze River Pharmaceutical Group Beijing Haiyan Pharmaceutical Co., Ltd., Beijing 102206, PR China. Electronic address: chendong@yangzijiang.com.
Wang Z; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: drwang@cpu.edu.cn.
Tan N; State Key Laboratory of Natural Medicines, Department of TCMs Pharmaceuticals, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing 211198, PR China. Electronic address: nhtan@cpu.edu.cn.

Biomed Pharmacother ; 118: 109188, 2019 Oct.

Article em En | MEDLINE | ID: mdl-31315072

Assuntos

Antitussígenos/uso terapêutico; Asma/tratamento farmacológico; Tosse/tratamento farmacológico; Medicamentos de Ervas Chinesas/uso terapêutico; Estresse do Retículo Endoplasmático/efeitos dos fármacos; Inflamassomos/metabolismo; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Animais; Antitussígenos/administração & dosagem; Asma/imunologia; Cápsulas; Tosse/imunologia; Modelos Animais de Doenças; Medicamentos de Ervas Chinesas/administração & dosagem; Estresse do Retículo Endoplasmático/imunologia; Masculino; Ovalbumina/imunologia; Ratos Wistar; Testes de Função Respiratória

Palavras-chave

4-Phenylbutyrate acid (CID: 4775); Cough variant asthma; Dexamethasone (CID: 5743); Endoplasmic reticulum stress; Inflammasome; Lipopolysaccharide (CID: 11970143); Mdivi-1 (CID: 3825829); NLRP3; Necrostatin-1 (CID: 2828334); Ovalbumin (CID: 56832351); Pulmonary dysfunction; Suhuang antitussive capsule; Tauroursodeoxycholic acid (CID: 9848818); Thapsigargin (CID: 446378); Tunicamycin (CID: 16760689)

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Assunto principal: Antitussígenos / Asma / Medicamentos de Ervas Chinesas / Tosse / Inflamassomos / Estresse do Retículo Endoplasmático / Proteína 3 que Contém Domínio de Pirina da Família NLR Tipo de estudo: Prognostic_studies Idioma: En Revista: Biomed Pharmacother Ano de publicação: 2019 Tipo de documento: Article

Texto completo

Adicionar na Minha BVS

Imprimir

XML

PubMed Links

Buscar no Google