A design for the photoelectrochemical detection of miRNA-221 based on a tungsten diselenide-cysteine-dopamine nanoprobe coupled with mismatched catalytic hairpin assembly target recycling with ultra-low background noise.

A strategy for the photoelectrochemical detection of miRNA with ultra-low background noise was developed using tungsten diselenide-cysteine-dopamine (WSe2/Cys/DA) as a nanoprobe coupled with mismatched catalytic hairpin assembly target recycling. A superior detection limit of 3.3 aM toward miRNA-221 was achieved.