Antihyperuricemic and anti-gouty arthritis activities of Aurantii fructus immaturus carbonisata-derived carbon dots.
Nanomedicine (Lond)
; 14(22): 2925-2939, 2019 11.
Article
em En
| MEDLINE
| ID: mdl-31418646
ABSTRACT
Aim:
To explore the antihyperuricemia and anti-gouty arthritis activities of Aurantii fructus immaturus carbonisata-derived carbon dots (AFIC-CDs). Materials &methods:
The AFIC-CDs were characterized using transmission electron microscopy; high-resolution transmission electron microscopy; ultraviolet, fluorescence, Fourier-transform infrared and x-ray photoelectron spectroscopy; high-performance liquid chromatography; and x-ray diffraction. Antihyperuricemia and anti-gouty arthritis activities of AFIC-CDs were explored in vivo and in vitro.Results:
The AFIC-CDs diameter ranged from 1.1 to 4.4 nm, with a yield of 7.2%. AFIC-CDs reduced serum uric acid by inhibiting xanthine oxidase activity in hyperuricemia rats and inhibited xanthine oxidase activity in vitro. AFIC-CDs improved gouty arthritis induced by monosodium urate crystals in vivo and in vitro.Conclusion:
AFIC-CDs may be a potential treatment for gout.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Assunto principal:
Carbono
/
Medicamentos de Ervas Chinesas
/
Artrite Gotosa
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Hiperuricemia
Idioma:
En
Revista:
Nanomedicine (Lond)
Ano de publicação:
2019
Tipo de documento:
Article