Disruption of an enhancer associated with addictive behaviour within the cannabinoid receptor-1 gene suggests a possible role in alcohol intake, cannabinoid response and anxiety-related behaviour.

Hay, Elizabeth A; McEwan, Andrew; Wilson, Dana; Barrett, Perry; D'Agostino, Giuseppe; Pertwee, Roger G; MacKenzie, Alasdair

Hay, Elizabeth A; McEwan, Andrew; Wilson, Dana; Barrett, Perry; D'Agostino, Giuseppe; Pertwee, Roger G; MacKenzie, Alasdair.

Afiliação

Hay EA; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
McEwan A; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Wilson D; Rowett Institute of Nutrition and Health, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Barrett P; Rowett Institute of Nutrition and Health, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
D'Agostino G; Rowett Institute of Nutrition and Health, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Pertwee RG; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK.
MacKenzie A; School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, Foresterhill, University of Aberdeen, Aberdeen AB25 2ZD, UK. Electronic address: mbi167@abdn.ac.uk.

Psychoneuroendocrinology ; 109: 104407, 2019 11.

Article em En | MEDLINE | ID: mdl-31445429

Assuntos

Consumo de Bebidas Alcoólicas/genética; Comportamento Aditivo/genética; Receptor CB1 de Canabinoide/genética; Animais; Ansiedade/genética; Transtornos de Ansiedade/genética; Encéfalo/metabolismo; Canabinoides/genética; Feminino; Predisposição Genética para Doença/genética; Genótipo; Hipocampo/metabolismo; Hipotálamo/metabolismo; Íntrons/genética; Desequilíbrio de Ligação/genética; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Polimorfismo de Nucleotídeo Único/genética; Receptor CB1 de Canabinoide/metabolismo

Palavras-chave

Anxiety-related behavior; CB(1) agonists; CRISPR genome editing; Cannabinoid-1 receptor; Enhancer; Ethanol intake; Gene regulation; Pharmacogenetics; Polymorphisms; Tissue specific; Win55,212-2

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Consumo de Bebidas Alcoólicas / Comportamento Aditivo / Receptor CB1 de Canabinoide Tipo de estudo: Risk_factors_studies Idioma: En Revista: Psychoneuroendocrinology Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Reino Unido

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