[The correlation of functional connectivity and structural connectivity between hippocampus and thalamus in Alzheimer's disease and amnestic mild cognitive impairment].
Zhonghua Nei Ke Za Zhi
; 58(9): 662-667, 2019 Sep 01.
Article
em Zh
| MEDLINE
| ID: mdl-31461817
ABSTRACT
Objective:
To investigate the correlation of functional connectivity (FC) and the integrity of connective fibres between hippocampus and thalamus in Alzheimer's disease(AD) and amnestic mild cognitive impairment (aMCI).Methods:
Both resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) data of 40 AD patients, 37 aMCI patients and 41 normal control subjects matching with age and educational level were collected. These subjects were all recruited from outpatient Department of Neurology in the Second Medical Center of Chinese PLA General Hospital, as well as poster, from May 2016 to January 2018. The FC strength between bilateral hippocampus and thalamus, as well as the parameters representing integrity of connective fibres, including fractional anisotropy (FA) and mean diffusivity(MD),were analyzed. Also, the correlations between FC strength and FA or MD strength were analyzed in the study.Results:
Compared to that of normal control subjects, the FC strength between billateral hippocampus and thalamus in patients with AD, aMCI were not significantly different(P>0.05). The integrity of bilateral connective fibres between hippocampus and thalamus were damaged in AD patients when compared to normal control subjects(P<0.01). A positive correlation of connective fibres integrity with FC strength between hippocampus and thalamus was found in the left side(r=0.25,P<0.05) but rather in the right side.Conclusion:
In AD and aMCI patients, structural connectivity between left hippocampus and thalamus affects the functional connectivity between them.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Tálamo
/
Doença de Alzheimer
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Disfunção Cognitiva
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Amnésia
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Hipocampo
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Rede Nervosa
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Idioma:
Zh
Revista:
Zhonghua Nei Ke Za Zhi
Ano de publicação:
2019
Tipo de documento:
Article