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A new bile acid from the traditional chinese medicine shedan.
Yuan, Yan; Wang, Qiu-Yan; Zhang, Jie; Nie, Jing; Zhou, Cheng-Gao; Yi, Wen-Qin; Wan, Luo-Sheng; Chen, Jia-Chun.
Afiliação
  • Yuan Y; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Wang QY; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Zhang J; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Nie J; Hubei Institute for Drug Control, Wuhan 430075, China.
  • Zhou CG; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Yi WQ; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Wan LS; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
  • Chen JC; Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Pharmaceutical Science Department of Tongji Medical School, Huazhong University of Science and Technology, Wuhan 430030, China.
J Asian Nat Prod Res ; 22(9): 879-885, 2020 Sep.
Article em En | MEDLINE | ID: mdl-31535572
ABSTRACT
A new bile acid tauro-16ß-hydroxy-12α-sulfate-5ß-cholenoic acid (1), along with six known ones (2-7), was isolated from the snake bile. Its planar structure and relative configuration were elucidated based on extensive spectroscopic analyses. Moreover, compound 2 showed inhibitory effect on NO production in RAW 264.7 macrophages at non-cytotoxic concentration (20 µM) with inhibitory rate of 69.7%. [Formula see text].
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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Bile / Medicina Tradicional Chinesa Tipo de estudo: Diagnostic_studies Idioma: En Revista: J Asian Nat Prod Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Bile / Medicina Tradicional Chinesa Tipo de estudo: Diagnostic_studies Idioma: En Revista: J Asian Nat Prod Res Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China