Flavanol-rich lychee fruit extract substantially reduces progressive cognitive and molecular deficits in a triple-transgenic animal model of Alzheimer disease.

Chen, Xiao; Xu, Benhong; Nie, Luling; He, Kaiwu; Zhou, Li; Huang, Xinfeng; Spencer, Peter; Yang, Xifei; Liu, Jianjun

Chen, Xiao; Xu, Benhong; Nie, Luling; He, Kaiwu; Zhou, Li; Huang, Xinfeng; Spencer, Peter; Yang, Xifei; Liu, Jianjun.

Afiliação

Chen X; Key Laboratory of Modern Toxicology of Shenzhen, Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, People's Republic of China.
Xu B; Key Laboratory of Modern Toxicology of Shenzhen, Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, People's Republic of China.
Nie L; Key Laboratory of Modern Toxicology of Shenzhen, Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, People's Republic of China.
He K; Key Laboratory of Modern Toxicology of Shenzhen, Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, People's Republic of China.
Zhou L; Key Laboratory of Modern Toxicology of Shenzhen, Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, People's Republic of China.
Huang X; Key Laboratory of Modern Toxicology of Shenzhen, Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, People's Republic of China.
Spencer P; Department of Neurology, School of Medicine, Oregon Institute of Occupational Health Sciences, Oregon Health and Science University, Portland, OR, USA.
Yang X; Key Laboratory of Modern Toxicology of Shenzhen, Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, People's Republic of China.
Liu J; Key Laboratory of Modern Toxicology of Shenzhen, Institute of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, People's Republic of China.

Nutr Neurosci ; 24(9): 720-734, 2021 Sep.

Article em En | MEDLINE | ID: mdl-31603034

Assuntos

Doença de Alzheimer/tratamento farmacológico; Catequina/análogos & derivados; Disfunção Cognitiva/tratamento farmacológico; Litchi/química; Fenóis/administração & dosagem; Extratos Vegetais/administração & dosagem; Doença de Alzheimer/genética; Peptídeos beta-Amiloides/metabolismo; Precursor de Proteína beta-Amiloide/genética; Animais; Catequina/administração & dosagem; Modelos Animais de Doenças; Flavonoides/administração & dosagem; Frutas/química; Hipocampo/efeitos dos fármacos; Hipocampo/metabolismo; Humanos; Masculino; Camundongos; Camundongos Transgênicos; Mutação/genética; Fosforilação/efeitos dos fármacos; Chá/química; Transgenes/genética; Proteínas tau/genética; Proteínas tau/metabolismo

Palavras-chave

Alzheimer's disease; Oligonol; amyloid beta; endoplasmic reticulum stress; inflammatory cytokines; mitochondrial dysfunction; proteasomal failure; synaptic loss; tau phosphrolation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fenóis / Extratos Vegetais / Catequina / Litchi / Doença de Alzheimer / Disfunção Cognitiva Idioma: En Revista: Nutr Neurosci Ano de publicação: 2021 Tipo de documento: Article

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