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Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity.
Feng, Zheling; Chen, Shixin; Wang, Wei; Feng, Lu; Dong, Yanyan; Zou, Yiping; Ke, Changqiang; Tang, Chunping; Yao, Sheng; Zhang, Haiyan; Gan, Lishe; Ye, Yang; Lin, Ligen.
Afiliação
  • Feng Z; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China.
  • Chen S; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310007, China.
  • Wang W; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Feng L; State Key Laboratory of Drug Research, & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Dong Y; College of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi 336000, China.
  • Zou Y; College of Chemistry and Bioengineering, Yichun University, Yichun, Jiangxi 336000, China.
  • Ke C; State Key Laboratory of Drug Research, & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Tang C; State Key Laboratory of Drug Research, & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Yao S; State Key Laboratory of Drug Research, & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Zhang H; CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China.
  • Gan L; College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310007, China. Electronic address: lsgan@zju.edu.cn.
  • Ye Y; State Key Laboratory of Drug Research, & Natural Products Chemistry Department, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; School of Life Science and Technology, Shanghai Tech University, Shanghai 201210, China. Electronic address: yye@simm.ac.cn.
  • Lin L; State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Taipa, Macau 999078, China. Electronic address: ligenl@um.edu.mo.
Fitoterapia ; 139: 104378, 2019 Nov.
Article em En | MEDLINE | ID: mdl-31676395
ABSTRACT
Five previously undescribed lycodine-type alkaloids, named huperzine Y (1), 8,15-epoxy-N-demethylhuperzinine (2), 7-hydroxyl-huperzinine (3), huperzine Z (4), and huperzine D N-oxide (5), were isolated from the aerial parts and roots of Lycopodiastrum casuarinoides (Lycopodiaceae), along with ten known analogues. The structures of the new compounds were elucidated by means of spectroscopic technique (IR, UV, MS and NMR). The absolute configurations of the new compounds were established on the basis of comparison of their experimental and TD-DFT (time-dependent density functional theory) calculated ECD spectra. Moreover, all the isolates were evaluated for acetylcholinesterase (AChE) inhibitory activity. Only huperzine C showed moderate activity, with an IC50 value of 0.525 ±â€¯0.140 µM, which was comparable with the positive control, huperzine A (IC50 = 0.143 ±â€¯0.029 µM).
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Colinesterase / Lycopodiaceae / Alcaloides / Compostos Heterocíclicos de 4 ou mais Anéis País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Inibidores da Colinesterase / Lycopodiaceae / Alcaloides / Compostos Heterocíclicos de 4 ou mais Anéis País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China