Lycodine-type alkaloids from Lycopodiastrum casuarinoides and their acetylcholinesterase inhibitory activity.
Fitoterapia
; 139: 104378, 2019 Nov.
Article
em En
| MEDLINE
| ID: mdl-31676395
ABSTRACT
Five previously undescribed lycodine-type alkaloids, named huperzine Y (1), 8,15-epoxy-N-demethylhuperzinine (2), 7-hydroxyl-huperzinine (3), huperzine Z (4), and huperzine D N-oxide (5), were isolated from the aerial parts and roots of Lycopodiastrum casuarinoides (Lycopodiaceae), along with ten known analogues. The structures of the new compounds were elucidated by means of spectroscopic technique (IR, UV, MS and NMR). The absolute configurations of the new compounds were established on the basis of comparison of their experimental and TD-DFT (time-dependent density functional theory) calculated ECD spectra. Moreover, all the isolates were evaluated for acetylcholinesterase (AChE) inhibitory activity. Only huperzine C showed moderate activity, with an IC50 value of 0.525⯱â¯0.140⯵M, which was comparable with the positive control, huperzine A (IC50â¯=â¯0.143⯱â¯0.029⯵M).
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Inibidores da Colinesterase
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Lycopodiaceae
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Alcaloides
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Compostos Heterocíclicos de 4 ou mais Anéis
País/Região como assunto:
Asia
Idioma:
En
Revista:
Fitoterapia
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
China