Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells.
Chem Commun (Camb)
; 55(94): 14162-14165, 2019 Dec 07.
Article
em En
| MEDLINE
| ID: mdl-31701102
ABSTRACT
A new class of BODIPY-based oxime ester photo-uncaging group was designed to release carboxylic acids. The mechanism and kinetics of the photo-uncaging procedure were studied. Further, we constructed a photo-uncaging drug delivery system to release valproic acid (VPA), which can inhibit the histone deacetylases and induce apoptosis in tumor cells.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Compostos de Boro
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Ácido Valproico
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Sistemas de Liberação de Medicamentos
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Apoptose
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Ésteres
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Histona Desacetilases
Idioma:
En
Revista:
Chem Commun (Camb)
Ano de publicação:
2019
Tipo de documento:
Article
País de afiliação:
Estados Unidos