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Photo-uncaging of BODIPY oxime ester for histone deacetylases induced apoptosis in tumor cells.
Sambath, Karthik; Zhao, Tinghan; Wan, Zhaoxiong; Zhang, Yuanwei.
Afiliação
  • Sambath K; Department of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King Jr. Blvd., Newark, NJ 07102, USA. yuanwei.zhang@njit.edu.
  • Zhao T; Department of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King Jr. Blvd., Newark, NJ 07102, USA. yuanwei.zhang@njit.edu.
  • Wan Z; Department of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King Jr. Blvd., Newark, NJ 07102, USA. yuanwei.zhang@njit.edu.
  • Zhang Y; Department of Chemistry and Environmental Science, College of Science and Liberal Arts, New Jersey Institute of Technology, 323 Martin Luther King Jr. Blvd., Newark, NJ 07102, USA. yuanwei.zhang@njit.edu.
Chem Commun (Camb) ; 55(94): 14162-14165, 2019 Dec 07.
Article em En | MEDLINE | ID: mdl-31701102
ABSTRACT
A new class of BODIPY-based oxime ester photo-uncaging group was designed to release carboxylic acids. The mechanism and kinetics of the photo-uncaging procedure were studied. Further, we constructed a photo-uncaging drug delivery system to release valproic acid (VPA), which can inhibit the histone deacetylases and induce apoptosis in tumor cells.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oximas / Compostos de Boro / Ácido Valproico / Sistemas de Liberação de Medicamentos / Apoptose / Ésteres / Histona Desacetilases Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oximas / Compostos de Boro / Ácido Valproico / Sistemas de Liberação de Medicamentos / Apoptose / Ésteres / Histona Desacetilases Idioma: En Revista: Chem Commun (Camb) Ano de publicação: 2019 Tipo de documento: Article País de afiliação: Estados Unidos