Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens.
Org Lett
; 22(1): 257-260, 2020 01 03.
Article
em En
| MEDLINE
| ID: mdl-31860319
Dactylicapnosines A (1) and B (2), two reconstructed aporphines with unprecedent five-membered carbon ring D, were isolated from Dactylicapnos scandens, in which dactylicapnosine A showed potent anti-inflammatory bioactivity in vitro. Inspired by its biosynthetic pathway, the total synthesis of dactylicapnosine A via 10 steps has been achieved and afforded enough material to prove its significant anti-inflammatory effect in vivo.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aporfinas
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Extratos Vegetais
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Anti-Inflamatórios não Esteroides
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Papaveraceae
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Analgésicos
Idioma:
En
Revista:
Org Lett
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China