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Exploring Aporphine as Anti-inflammatory and Analgesic Lead from Dactylicapnos scandens.
Wang, Bei; Zhao, Yin-Jiao; Zhao, Yun-Li; Liu, Ya-Ping; Li, Xiao-Nian; Zhang, Hongbin; Luo, Xiao-Dong.
Afiliação
  • Wang B; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , 650201 , China.
  • Zhao YJ; Key Laboratory of Herbal-Tebitan Drug Screening and Deep Processing of Gansu Province, School of Life Science and Engineering , Lanzhou University of Technology , Lanzhou 730050 , China.
  • Zhao YL; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
  • Liu YP; Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education and Yunnan Province, School of Chemical Science and Technology , Yunnan University , Kunming 650091 , China.
  • Li XN; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , 650201 , China.
  • Zhang H; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , 650201 , China.
  • Luo XD; State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming , 650201 , China.
Org Lett ; 22(1): 257-260, 2020 01 03.
Article em En | MEDLINE | ID: mdl-31860319
Dactylicapnosines A (1) and B (2), two reconstructed aporphines with unprecedent five-membered carbon ring D, were isolated from Dactylicapnos scandens, in which dactylicapnosine A showed potent anti-inflammatory bioactivity in vitro. Inspired by its biosynthetic pathway, the total synthesis of dactylicapnosine A via 10 steps has been achieved and afforded enough material to prove its significant anti-inflammatory effect in vivo.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aporfinas / Extratos Vegetais / Anti-Inflamatórios não Esteroides / Papaveraceae / Analgésicos Idioma: En Revista: Org Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Aporfinas / Extratos Vegetais / Anti-Inflamatórios não Esteroides / Papaveraceae / Analgésicos Idioma: En Revista: Org Lett Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China