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Four new corynanthe-type alkaloids from the roots of Alstonia scholaris.
Zhang, Jian; Li, Hua; Li, Yong; Li, Zi-Wei; Sang, Chen-Chen; Gao, Mei-Hua; Zhang, Dong-Mei; Zhang, Xiao-Qi; Ye, Wen-Cai.
Afiliação
  • Zhang J; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Li H; Chinese Patent Medicine Department, Guangdong Institute for Drug Control, Guangzhou 510663, China.
  • Li Y; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Li ZW; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Sang CC; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Gao MH; Chinese Patent Medicine Department, Guangdong Institute for Drug Control, Guangzhou 510663, China.
  • Zhang DM; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China.
  • Zhang XQ; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: xqzhang74@hotmail.com.
  • Ye WC; Institute of Traditional Chinese Medicine & Natural Products, and Guangdong Provincial Engineering Research Center for Modernization of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China. Electronic address: chywc@aliyun.com.
Chin J Nat Med ; 17(12): 918-923, 2019 Dec.
Article em En | MEDLINE | ID: mdl-31882046
ABSTRACT
Four new corynanthe-type alkaloids, meloslines C-F (1-4), together with four known ones (5-8) were isolated from the roots of Alstonia scholaris. Their structures including absolute configurations were elucidated by extensive spectroscopic analysis and electronic circular dichroism (ECD) calculation. Compounds 1 and 2 exhibited potent vasorelaxant activity on endothelium-intact renal arteries precontracted with KCl.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vasodilatadores / Raízes de Plantas / Alstonia / Pausinystalia / Alcaloides País/Região como assunto: Asia Idioma: En Revista: Chin J Nat Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vasodilatadores / Raízes de Plantas / Alstonia / Pausinystalia / Alcaloides País/Região como assunto: Asia Idioma: En Revista: Chin J Nat Med Ano de publicação: 2019 Tipo de documento: Article País de afiliação: China