Zn2+-assisted photothermal therapy for rapid bacteria-killing using biodegradable humic acid encapsulated MOFs.
Colloids Surf B Biointerfaces
; 188: 110781, 2020 Apr.
Article
em En
| MEDLINE
| ID: mdl-31935632
ABSTRACT
Bacterial infection is seriously threatening human health all over the world, especially with the emergence of increasing drug-fast bacteria. It is urgent to develop a drug-free strategy to kill bacteria rapidly and efficiently. In this work, humic acid (HuA) encapsulated zeolitic imidazole framework-8 (ZIF-8) (HuA@ZIF-8) nanocomposites are synthesized by the in-situ growth of ZIF-8 on the surface of polyvinylpyrrolidone (PVP)-modified HuA. The synthesized nanocomposites possesses good photothermal effects, i.e., the temperature increased to 59.4⯰C under the particle concentration of 1000⯵g/mL with 10â¯min NIR irradiation. In addition, NIR irradiation can also control the release of Zn2+ from the composites. The good photothermal effects originate from HuA that can effectively absorb NIR light. The controlled release of Zn2+ is ascribed to the induced-dissociation of ZIF-8 under NIR light irradiation. The synergistic action of photothermal therapy and release of zinc ions contributes to the excellent antibacterial efficiency of HuA@ZIF-8 within a short time, i.e. 99.59 % and 99.37 % against Staphylococcus aureus and Escherichia coli with 20â¯min NIR irradiation, respectively. This work provides a promising strategy to develop a light-responsive platform with good biodegradability and low cost for rapid and effective sterilization.
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Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Plantas_medicinales
Assunto principal:
Fototerapia
/
Zinco
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Estruturas Metalorgânicas
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Substâncias Húmicas
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Antibacterianos
Idioma:
En
Revista:
Colloids Surf B Biointerfaces
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China