Vitamin D suppresses proangiogenic factors in patients with ulcerative colitis: A randomized double blind placebo controlled clinical trial.
Complement Ther Clin Pract
; 39: 101086, 2020 May.
Article
em En
| MEDLINE
| ID: mdl-31957666
ABSTRACT
BACKGROUND:
Angiogenesis and inflammation are involved in the pathogenesis of ulcerative colitis (UC). This study aimed to assess the effect of vitamin D on serum levels of proangiogenic factors, visfatin and vascular endothelial growth factor (VEGF), in patients with UC. MATERIALS ANDMETHODS:
Ninety patients were randomized to receive either a single intramuscular injection of 300,000 IU vitamin D or normal saline. Visfatin, VEGF, and 25-hydroxyvitamin D [25(OH)D] concentrations were assessed before and 90 days after the intervention.RESULTS:
There were no significant differences in visfatin and VEGF levels between the two groups following supplementation. In patients with vitamin D insufficiency, visfatin increase was significantly lower in the intervention versus placebo group. There was an inverse correlation between serum 25(OH)D and visfatin in the subgroup with vitamin D insufficiency.CONCLUSION:
Vitamin D might be beneficial in decreasing proangiogenic factors such as visfatin in UC patients with low 25(OH)D levels.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Vitamina D
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Deficiência de Vitamina D
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Colite Ulcerativa
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Citocinas
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Neovascularização Fisiológica
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Fator A de Crescimento do Endotélio Vascular
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Nicotinamida Fosforribosiltransferase
Tipo de estudo:
Clinical_trials
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Etiology_studies
Idioma:
En
Revista:
Complement Ther Clin Pract
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Irã