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Vitamin B12 concentrations in milk from Norwegian women during the six first months of lactation.
Henjum, Sigrun; Manger, Mari; Hampel, Daniela; Brantsæter, Anne Lise; Shahab-Ferdows, Setareh; Bastani, Nasser E; Strand, Tor A; Refsum, Helga; Allen, Lindsay H.
Afiliação
  • Henjum S; Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130, Oslo, Norway. shenjum@oslomet.no.
  • Manger M; Children's Hospital Oakland Research Institute, Oakland, CA, 94609, USA.
  • Hampel D; USDA/ARS Western Human Nutrition Research Center, Davis, CA, 95616, USA.
  • Brantsæter AL; Department of Nutrition, University of California, Davis, CA, 95616, USA.
  • Shahab-Ferdows S; Division of Infection Control, Environment and Health, Norwegian Institute of Public Health, 0213, Oslo, Norway.
  • Bastani NE; USDA/ARS Western Human Nutrition Research Center, Davis, CA, 95616, USA.
  • Strand TA; Department of Nutrition, Institute of Medical Biosciences, University of Oslo, 0317, Oslo, Norway.
  • Refsum H; Department of Research, Innlandet Hospital Trust, 2380, Brumunddal, Norway.
  • Allen LH; Centre for International Health, University of Bergen, 5020, Bergen, Norway.
Eur J Clin Nutr ; 74(5): 749-756, 2020 05.
Article em En | MEDLINE | ID: mdl-32001810
BACKGROUND: Human milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries. OBJECTIVE: We assessed human milk B12 concentrations during the first 6 months postpartum in Norwegian women and its association with maternal dietary B12 intake and maternal urinary methylmalonic acid (MMA) concentration. METHODS: In this cross-sectional study, 175 mothers, exclusively (80%) or partially (20%) breastfeeding, were included. Milk B12 was measured by IMMULITE®/IMMULITE® 1000 B12 competitive protein binding assay and urinary MMA relative to creatinine (MMA/Cr) by liquid chromatography-tandem-mass spectrometry. Maternal habitual B12 intake and supplement use were estimated using a food frequency questionnaire. RESULTS: Mean human milk B12 concentration was 327 pmol/L (range 140-1089), with 402 pmol/L at 1 month (n = 21), 333 pmol/L at four months (n = 32), and 299 pmol/L at 6 months (n = 21). Maternal B12 intake was 5 µg/d, 89% met the Estimated Average Requirement, and supplement use did not affect milk B12 concentrations. MMA/Cr was low in all women compared with published data. In exclusively breastfeeding women, MMA/Cr (beta (95% CI) -42.5 (-82.5, -2.5) and time since birth (-4.9 (-9.6, -0.3)) were significant predictors of human milk B12 concentrations. There was no association between total B12 intake and milk B12 concentration or between total B12 intake and MMA/Cr. CONCLUSIONS: Maternal B12 status and human milk B12 concentrations are likely sufficient, based on adequate maternal B12 dietary intake combined with low urinary MMA concentrations. Nevertheless, milk B12 concentration fell during 6 months postpartum while maternal B12 status did not change.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina B 12 / Lactação / Leite Humano Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies País/Região como assunto: Europa Idioma: En Revista: Eur J Clin Nutr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Noruega

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Vitamina B 12 / Lactação / Leite Humano Tipo de estudo: Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies País/Região como assunto: Europa Idioma: En Revista: Eur J Clin Nutr Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Noruega