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Striatal and Thalamic Auditory Response During Deep Brain Stimulation for Essential Tremor: Implications for Psychosis.
Gault, Judith M; Thompson, John A; Maharajh, Keeran; Hosokawa, Patrick; Stevens, Karen E; Olincy, Ann; Liedtke, Erin I; Ojemann, Alex; Ojemann, Steven; Abosch, Aviva.
Afiliação
  • Gault JM; Department of Neurosurgery, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
  • Thompson JA; Department of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
  • Maharajh K; Department of Neurosurgery, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
  • Hosokawa P; Department of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
  • Stevens KE; Department of Neurology, University of Colorado Denver, Anschutz Medical Campus, Aurora, CO, USA.
  • Olincy A; Department of Neurosurgery, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
  • Liedtke EI; Department of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
  • Ojemann A; Department of Psychiatry, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
  • Ojemann S; Department of Neurosurgery, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
  • Abosch A; Department of Neurosurgery, University of Colorado Denver Anschutz Medical Campus, Aurora, CO, USA.
Neuromodulation ; 23(4): 478-488, 2020 Jun.
Article em En | MEDLINE | ID: mdl-32022409
ABSTRACT

INTRODUCTION:

The P50, a positive auditory-evoked potential occurring 50 msec after an auditory click, has been characterized extensively with electroencephalography (EEG) to detect aberrant auditory electrophysiology in disorders like schizophrenia (SZ) where 61-74% have an auditory gating deficit. The P50 response occurs in primary auditory cortex and several thalamocortical regions. In rodents, the gated P50 response has been identified in the reticular thalamic nucleus (RT)-a deep brain structure traversed during deep brain stimulation (DBS) targeting of the ventral intermediate nucleus (VIM) of the thalamus to treat essential tremor (ET) allowing for interspecies comparison. The goal was to utilize the unique opportunity provided by DBS surgery for ET to map the P50 response in multiple deep brain structures in order to determine the utility of intraoperative P50 detection for facilitating DBS targeting of auditory responsive subterritories. MATERIALS AND

METHODS:

We developed a method to assess P50 response intraoperatively with local field potentials (LFP) using microelectrode recording during routine clinical electrophysiologic mapping for awake DBS surgery in seven ET patients. Recording sites were mapped into a common stereotactic space.

RESULTS:

Forty significant P50 responses of 155 recordings mapped to the ventral thalamus, RT and CN head/body interface at similar rates of 22.7-26.7%. P50 response exhibited anatomic specificity based on distinct positions of centroids of positive and negative responses within brain regions and the fact that P50 response was not identified in the recordings from either the internal capsule or the dorsal thalamus.

CONCLUSIONS:

Detection of P50 response intraoperatively may guide DBS targeting RT and subterritories within CN head/body interface-DBS targets with the potential to treat psychosis and shown to modulate schizophrenia-like aberrancies in mouse models.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Tálamo / Corpo Estriado / Tremor Essencial / Estimulação Encefálica Profunda / Potenciais Evocados Auditivos Idioma: En Revista: Neuromodulation Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Psicóticos / Tálamo / Corpo Estriado / Tremor Essencial / Estimulação Encefálica Profunda / Potenciais Evocados Auditivos Idioma: En Revista: Neuromodulation Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos