Endothelin-1 Mediated Decrease in Mitochondrial Gene Expression and Bioenergetics Contribute to Neurodegeneration of Retinal Ganglion Cells.

Chaphalkar, Renuka M; Stankowska, Dorota L; He, Shaoqing; Kodati, Bindu; Phillips, Nicole; Prah, Jude; Yang, Shaohua; Krishnamoorthy, Raghu R

Chaphalkar, Renuka M; Stankowska, Dorota L; He, Shaoqing; Kodati, Bindu; Phillips, Nicole; Prah, Jude; Yang, Shaohua; Krishnamoorthy, Raghu R.

Afiliação

Chaphalkar RM; North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, UNT Health Science Center, Fort Worth, Texas, 76107, United States.
Stankowska DL; North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, UNT Health Science Center, Fort Worth, Texas, 76107, United States.
He S; North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, UNT Health Science Center, Fort Worth, Texas, 76107, United States.
Kodati B; North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, UNT Health Science Center, Fort Worth, Texas, 76107, United States.
Phillips N; Department of Microbiology, Immunology and Genetics, UNT Health Science Center, Fort Worth, Texas, 76107, United States.
Prah J; Department of Basic and Translational Sciences, School of Dental Medicine, University of Pennsylvania, Philadelphia, PA, 19104, United States.
Yang S; North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, UNT Health Science Center, Fort Worth, Texas, 76107, United States.
Krishnamoorthy RR; North Texas Eye Research Institute, Department of Pharmacology and Neuroscience, UNT Health Science Center, Fort Worth, Texas, 76107, United States. raghu.krishnamoorthy@unthsc.edu.

Sci Rep ; 10(1): 3571, 2020 02 27.

Article em En | MEDLINE | ID: mdl-32107448

Assuntos

Endotelina-1/metabolismo; Glaucoma/metabolismo; Mitocôndrias/genética; Células Ganglionares da Retina/metabolismo; Animais; Proteínas de Transporte de Cobre/genética; Proteínas de Transporte de Cobre/metabolismo; Modelos Animais de Doenças; Endotelina-1/genética; Metabolismo Energético; Feminino; Expressão Gênica; Glaucoma/genética; Glaucoma/fisiopatologia; Humanos; Masculino; Mitocôndrias/metabolismo; ATPases Mitocondriais Próton-Translocadoras/genética; ATPases Mitocondriais Próton-Translocadoras/metabolismo; Degeneração Neural; Ratos; Ratos Endogâmicos BN

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Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_energeticas / Bioenergetica Assunto principal: Células Ganglionares da Retina / Glaucoma / Endotelina-1 / Mitocôndrias Tipo de estudo: Prognostic_studies Idioma: En Revista: Sci Rep Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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