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Cytotoxic aspidosperma-type alkaloids from Melodinus suaveolens.
Fang, Zhong-Ying; He, Tian-Tian; Du, Si-Yu; Zhang, Miao; Zhang, Yong-Qing; Fang, Lei.
Afiliação
  • Fang ZY; Key laboratory of Natural Pharmaceutical Chemistry, Shandong University of Traditional Chinese Medicine, Jinan 250200, China; School of Biological Science and Technology, University of Jinan, Jinan 250022, PR China.
  • He TT; School of Biological Science and Technology, University of Jinan, Jinan 250022, PR China.
  • Du SY; Key laboratory of Natural Pharmaceutical Chemistry, Shandong University of Traditional Chinese Medicine, Jinan 250200, China.
  • Zhang M; School of Biological Science and Technology, University of Jinan, Jinan 250022, PR China.
  • Zhang YQ; Key laboratory of Natural Pharmaceutical Chemistry, Shandong University of Traditional Chinese Medicine, Jinan 250200, China.
  • Fang L; Key laboratory of Natural Pharmaceutical Chemistry, Shandong University of Traditional Chinese Medicine, Jinan 250200, China; School of Biological Science and Technology, University of Jinan, Jinan 250022, PR China. Electronic address: bio_fangl@ujn.edu.cn.
Fitoterapia ; 143: 104588, 2020 Jun.
Article em En | MEDLINE | ID: mdl-32272162
ABSTRACT
Four new aspidosperma-type alkaloids, melosuavines J-M (1-4) were isolated from the leaves of Melodinus suaveolens. Their structures with absolute configurations were elucidated by extensive HRESIMS and NMR spectroscopic analysis, as well as ECD calculations and Mosher's method. Their cytotoxic activities against four human cancer cell lines were also evaluated.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Folhas de Planta / Apocynaceae / Alcaloides / Antineoplásicos Fitogênicos País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Folhas de Planta / Apocynaceae / Alcaloides / Antineoplásicos Fitogênicos País/Região como assunto: Asia Idioma: En Revista: Fitoterapia Ano de publicação: 2020 Tipo de documento: Article