Effects of dietary intake of heat-inactivated Lactobacillus gasseri CP2305 on stress-induced behavioral and molecular changes in a subchronic and mild social defeat stress mouse model.
Biomed Res
; 41(2): 101-111, 2020.
Article
em En
| MEDLINE
| ID: mdl-32307337
ABSTRACT
The intestinal ecosystem is involved in the pathogenesis of mood disorders such as depression. Intestinal microbes can affect the central nervous system through the gut-brain axis, which raises the possibility of using probiotics for preventing depression. In this study, we examined the effect of heat-inactivated Lactobacillus gasseri CP2305 (CP2305) in a subchronic and mild social defeat stress (sCSDS) mouse model. sCSDS suppressed food intake. However, dietary CP2305 intake rescued it, suggesting that CP2305 improved the decreased appetite in sCSDS mice. sCSDS did not alter the gene expression of brain-derived neurotrophic factor, nerve growth factor, and neurotrophin-3 in the hippocampus. However, dietary CP2305 provided following sCSDS increased the gene expression of these neurotrophins in the hippocampus. These findings suggest that CP2305 supplementation would aid in preventing psychosocial stress-induced disorders.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Estresse Psicológico
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Comportamento Animal
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Regulação da Expressão Gênica
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Ingestão de Alimentos
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Lactobacillus gasseri
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Temperatura Alta
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Hipocampo
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Biomed Res
Ano de publicação:
2020
Tipo de documento:
Article