Immune modulating effects of additional supplementation of estradiol combined with testosterone in murine testosterone-deficient NAFLD model.

Okamura, Takuro; Hamaguchi, Masahide; Bamba, Ryo; Nakajima, Hanako; Yoshimura, Yuta; Kimura, Tomonori; Nishida, Kensuke; Hashimoto, Yoshitaka; Fukuda, Takuya; Senmaru, Takafumi; Fukui, Michiaki

Okamura, Takuro; Hamaguchi, Masahide; Bamba, Ryo; Nakajima, Hanako; Yoshimura, Yuta; Kimura, Tomonori; Nishida, Kensuke; Hashimoto, Yoshitaka; Fukuda, Takuya; Senmaru, Takafumi; Fukui, Michiaki.

Afiliação

Okamura T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Hamaguchi M; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Bamba R; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Nakajima H; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Yoshimura Y; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Kimura T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Nishida K; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Hashimoto Y; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Fukuda T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Senmaru T; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Fukui M; Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Am J Physiol Gastrointest Liver Physiol ; 318(6): G989-G999, 2020 06 01.

Article em En | MEDLINE | ID: mdl-32363890

Assuntos

Estradiol/farmacologia; Hepatopatia Gordurosa não Alcoólica/prevenção & controle; Testosterona/farmacologia; Aminoácidos; Animais; Carcinoma Hepatocelular; Linhagem Celular Tumoral; Cromo; Colágeno Tipo I/genética; Colágeno Tipo I/metabolismo; Cadeia alfa 1 do Colágeno Tipo I; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Dieta Hiperlipídica/efeitos adversos; Regulação para Baixo; Estradiol/administração & dosagem; Regulação da Expressão Gênica/efeitos dos fármacos; Humanos; Insulina; Cirrose Hepática; Neoplasias Hepáticas; Masculino; Camundongos; Camundongos Knockout; Ácidos Nicotínicos; Hepatopatia Gordurosa não Alcoólica/patologia; Orquiectomia; Células RAW 264.7; RNA Mensageiro/genética; RNA Mensageiro/metabolismo; Receptores CCR2/genética; Receptores CCR2/metabolismo; Testosterona/administração & dosagem; Testosterona/deficiência; Fator de Crescimento Transformador beta1/genética; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

ILC3; M2 macrophage; NASH; innate immunity; sex hormones

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Testosterona / Estradiol / Hepatopatia Gordurosa não Alcoólica Tipo de estudo: Prognostic_studies Idioma: En Revista: Am J Physiol Gastrointest Liver Physiol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Japão

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