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Neural regulation of energy and bone homeostasis by the synaptic adhesion molecule Calsyntenin-3.
Kim, Sung-Jin; Jeong, Yong Taek; Jeong, Se Rok; Park, Munsu; Go, Hye Sun; Kim, Mi Young; Seong, Je Kyung; Kim, Ki Woo; Seo, Jeong Taeg; Kim, Chul Hoon; Lee, Ji Hyun; Moon, Seok Jun.
Afiliação
  • Kim SJ; Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
  • Jeong YT; Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
  • Jeong SR; Department of Pharmacology, Korea University College of Medicine, Seoul, 02841, Korea.
  • Park M; Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
  • Go HS; Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul, Korea.
  • Kim MY; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
  • Seong JK; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
  • Kim KW; Korea Mouse Phenotyping Center (KMPC), Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul, 08826, Korea.
  • Seo JT; Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
  • Kim CH; Department of Oral Biology, BK21 PLUS Project, Yonsei University College of Dentistry, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
  • Lee JH; Department of Pharmacology, Yonsei University College of Medicine, Yonsei-ro 50-1, Seodaemun-gu, Seoul, 03722, Korea.
  • Moon SJ; Department of Clinical Pharmacology and Therapeutics, College of Medicine, Kyung Hee University, Seoul, Korea.
Exp Mol Med ; 52(5): 793-803, 2020 05.
Article em En | MEDLINE | ID: mdl-32382066
Neuronal regulation of energy and bone metabolism is important for body homeostasis. Many studies have emphasized the importance of synaptic adhesion molecules in the formation of synapses, but their roles in physiology still await further characterization. Here, we found that the synaptic adhesion molecule Calsyntenin-3 (CLSTN3) regulates energy and bone homeostasis. Clstn3 global knockout mice show reduced body mass with improved leptin sensitivity and increased energy expenditure compared to their wild-type littermates. In addition, Clstn3 knockout mice show reduced marrow volume and cortical bone mass without alteration of trabecular bone microarchitecture. This reduced bone mass is not bone cell-autonomous because neither osteoblast- nor osteoclast-specific Clstn3 knockout mice show bone defects; similarly, in vitro cultures of both Clstn3 knockout osteoblasts and osteoclasts do not show any defects. These reduced body and bone mass phenotypes can be attributed instead to neuronal CLSTN3 because they are recapitulated by pan-neuronal but not sympathetic neuron-specific deletion of Clstn3. This study reveals novel physiological functions of neuronal Clstn3 as a key regulator of energy and bone homeostasis.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinapses / Osso e Ossos / Proteínas de Ligação ao Cálcio / Metabolismo Energético / Homeostase / Proteínas de Membrana / Neurônios Idioma: En Revista: Exp Mol Med Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sinapses / Osso e Ossos / Proteínas de Ligação ao Cálcio / Metabolismo Energético / Homeostase / Proteínas de Membrana / Neurônios Idioma: En Revista: Exp Mol Med Ano de publicação: 2020 Tipo de documento: Article