Treatment of bullous pemphigoid in Chinese patients with Tripterygium wilfordii Hook F.
Dermatol Ther
; 33(4): e13721, 2020 07.
Article
em En
| MEDLINE
| ID: mdl-32500934
ABSTRACT
Tripterygium wilfordii Hook F (TwHF) is a traditional Chinese herb used in many medicinal applications, but the treatment of bullous pemphigoid (BP) with TwHF has never been reported. The aim of this study was to evaluate the efficacy and safety of TwHF in BP patients. A retrospective study was performed from January 2015 to September 2019 in the Department of Dermatology, Peking Union Medical College Hospital. A total of 10 patients with mild to moderate BP and treated with TwHF were enrolled in the study with 10 mild or moderate BP patients treated with systemic glucocorticoid randomly selected as controls. In the TwHF group, a major response was seen in seven patients, a minor response in one and no response was seen in two patients. In the glucocorticoid group, a major response was seen in nine patients and a minor response in one patient. Two patients experienced treatment failure. The time to disease control in the TwHF group (34 ± 11 days) was longer as compared to the glucocorticoid group (18 ± 8 days, P < .05). Ten patients relapsed during the follow-up period. The adverse events in the TwHF group were lower than those in the glucocorticoid group (13 vs 19). Low-dose TwHF may be effective and safe for treating mild and moderate BP.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
Assunto principal:
Penfigoide Bolhoso
/
Tripterygium
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
Dermatol Ther
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China