Ginsenoside Rg1 prevents vascular intimal hyperplasia involved by SDF-1&#945;/CXCR4, SCF/c-kit and FKN/CX3CR1 axes in a rat balloon injury.

Hu, Anling; Shuai, Zhiqin; Liu, Jiajia; Huang, Bo; Luo, Yunmei; Deng, Jiang; Liu, Jie; Yu, Limei; Li, Lisheng; Xu, Shangfu

Ginsenoside Rg1 prevents vascular intimal hyperplasia involved by SDF-1α/CXCR4, SCF/c-kit and FKN/CX3CR1 axes in a rat balloon injury.

Hu, Anling; Shuai, Zhiqin; Liu, Jiajia; Huang, Bo; Luo, Yunmei; Deng, Jiang; Liu, Jie; Yu, Limei; Li, Lisheng; Xu, Shangfu.

Afiliação

Hu A; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China; State Key Laboratory for Functions and Applications of Medicinal Plants, Guizhou Medical Univer
Shuai Z; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China; Department of Pharmacology, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 56300
Liu J; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China; Department of Pharmacology, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 56300
Huang B; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China. Electronic address: zmc.hb@foxmail.com.
Luo Y; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China. Electronic address: 15022335973@163.com.
Deng J; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China. Electronic address: 107087512@qq.com.
Liu J; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China. Electronic address: Jie@liuonline.com.
Yu L; State Key Laboratory of Cell Engineering of Guizhou Province, The Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, 563003, China. Electronic address: ylm720@sina.com.
Li L; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China. Electronic address: medlls@sina.com.
Xu S; Key Laboratory of Basic Pharmacology of Ministry of Education and Joint International Research Laboratory of Ethnocentric of Ministry of Education, Zunyi Medical University, Zunyi, Guizhou, 563000, China; Department of Pharmacology, School of Pharmacy, Zunyi Medical University, Zunyi, Guizhou, 56300

J Ethnopharmacol ; 260: 113046, 2020 Oct 05.

Article em En | MEDLINE | ID: mdl-32504784

Assuntos

Receptor 1 de Quimiocina CX3C/metabolismo; Lesões das Artérias Carótidas/prevenção & controle; Quimiocina CX3CL1/metabolismo; Quimiocina CXCL12/metabolismo; Ginsenosídeos/farmacologia; Músculo Liso Vascular/efeitos dos fármacos; Neointima; Proteínas Proto-Oncogênicas c-kit/metabolismo; Receptores CXCR4/metabolismo; Fator de Células-Tronco/metabolismo; Angioplastia com Balão; Animais; Lesões das Artérias Carótidas/etiologia; Lesões das Artérias Carótidas/metabolismo; Lesões das Artérias Carótidas/patologia; Artéria Carótida Primitiva/efeitos dos fármacos; Artéria Carótida Primitiva/metabolismo; Artéria Carótida Primitiva/patologia; Modelos Animais de Doenças; Hiperplasia; Masculino; Músculo Liso Vascular/lesões; Músculo Liso Vascular/metabolismo; Músculo Liso Vascular/patologia; Ratos Sprague-Dawley; Transdução de Sinais

Palavras-chave

FKN/CX3CR1; Ginsenoside Rg1; SCF/c-Kit; SDF-1α/CXCR4; Smooth muscle progenitor cells

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Fator de Células-Tronco / Proteínas Proto-Oncogênicas c-kit / Receptores CXCR4 / Lesões das Artérias Carótidas / Ginsenosídeos / Quimiocina CXCL12 / Quimiocina CX3CL1 / Neointima / Receptor 1 de Quimiocina CX3C / Músculo Liso Vascular Tipo de estudo: Etiology_studies / Prognostic_studies Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2020 Tipo de documento: Article

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