[Usefulness of immature platelet fraction measurement for diagnosis and monitoring of iron deficiency associated thrombocytopenia: about two cases]. / Apport de la mesure de la fraction de plaquettes immatures dans le diagnostic et le suivi des thrombopénies ferriprives : à propos de deux cas.
Ann Biol Clin (Paris)
; 78(4): 433-437, 2020 08 01.
Article
em Fr
| MEDLINE
| ID: mdl-32576540
ABSTRACT
Iron deficiency anemia is frequently associated with thrombocytosis. However, in some rare cases of very severe iron deficiency, a thrombocytopenia may occur. This condition may lead to a misdiagnosis of immune thrombocytopenic purpura and thus to unnecessary tests in this context. Here we report two patients who presented with iron deficiency associated thrombocytopenia rapidly corrected after martial supplementation. We then discuss the value of measuring immature platelet fraction (IPF), which represents the population of newly formed platelets containing a greater amount of residual RNA. For both cases, low IPF values at admission indicated a central origin of thrombocytopenia with decreased platelet production, which is the pathophysiological mechanism of iron deficiency associated thrombocytopenia.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trombocitopenia
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Plaquetas
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Anemia Ferropriva
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Monitorização Fisiológica
Tipo de estudo:
Diagnostic_studies
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Prognostic_studies
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Risk_factors_studies
Idioma:
Fr
Revista:
Ann Biol Clin (Paris)
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
França