The clinical impact of cross-reactions between allergens on allergic skin diseases.
Curr Opin Allergy Clin Immunol
; 20(4): 374-380, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-32590506
ABSTRACT
PURPOSE OF REVIEW The route of allergen sensing via the skin appears to influence the immune system towards mounting a type 2 response, especially in genetically predisposed individuals. Allergens recognized this way may derive from microbial, animal, food, or other plant sources and trigger atopic dermatitis. Allergens can be grouped into families depending on their structure and function, harboring significant structural and sequence similarities. Cross-reactivity between allergens is believed to arise as a consequence, and to underlie the development of further atopic diseases. RECENT FINDINGS:
Especially for the plant allergens of the families of PR10-related proteins and profilins, immune cross-reactions have been described. Actual studies support that food and pollen allergens can aggravate skin lesions in patients suffering from atopic dermatitis. Further on, allergens derived from air-borne or skin-borne fungi belong to common allergen families and bear cross-reactivity potential. Cross-reactivity to human homologous proteins, so-called autoallergens, is discussed to contribute to the chronification of atopic dermatitis.SUMMARY:
Due to high evolutionary conservation, allergic reactions can be triggered by highly homologous members of allergen families on the humoral as well as on the cellular level.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Pele
/
Alérgenos
/
Dermatite Atópica
/
Hipersensibilidade Alimentar
Tipo de estudo:
Etiology_studies
Idioma:
En
Revista:
Curr Opin Allergy Clin Immunol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Áustria