Evaluation of the effect of hyperbaric oxygen therapy on hypertrophic scar formation in a rabbit ear model: An experimental study.
Dermatol Ther
; 33(6): e14146, 2020 11.
Article
em En
| MEDLINE
| ID: mdl-32761727
ABSTRACT
Hypertrophic scar is a disease with complicated treatment methods. Although there are numerous studies in the literature definitive therapy has not been reported yet. In this study, we aimed to evaluate the short and long-term effects of HBOT on hypertrophic scar formation in a rabbit ear model. A total of 20 male New Zealand rabbits weighing 2.1 to 2.4 kg were used in this study. The rabbits in group 2 were exposed to hyperbaric oxygen treatment for 7 days starting from the first day following biopsy punch, while no extra treatment was applied to the rabbits in group 1. Macroscopic scar thickness, histopathological parameters and HI were assessed in both of the 30th day and 60th day scars. Scar thickness was found significantly less in the scars of the rabbits exposed to HBOT (P < .05). And less dermal hypertrophy was also found in HI results of group 2.(P ≈ .022) There were differences between groups in terms of inflammation, vascularization and density of collagen fibrils. HBOT applied for 7 days from the first day of wound formation has both short and long-term effects on the triggering factors of hypertrophic scar, especially on inflammation.
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Texto completo:
1
Base de dados:
MEDLINE
Métodos Terapêuticos e Terapias MTCI:
Terapias_biologicas
/
Oxigenoterapia_hiperbrica
Assunto principal:
Cicatriz Hipertrófica
/
Oxigenoterapia Hiperbárica
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Idioma:
En
Revista:
Dermatol Ther
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Turquia