Combination of MS Binding Assays and affinity selection mass spectrometry for screening of structurally homogenous libraries as exemplified for a focused oxime library addressing the neuronal GABA transporter 1.

Gabriel, Jürgen; Höfner, Georg; Wanner, Klaus T

Gabriel, Jürgen; Höfner, Georg; Wanner, Klaus T.

Afiliação

Gabriel J; Faculty of Chemistry and Pharmacy, Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Höfner G; Faculty of Chemistry and Pharmacy, Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany.
Wanner KT; Faculty of Chemistry and Pharmacy, Department of Pharmacy - Center for Drug Research, Ludwig-Maximilians-Universität München, Munich, Germany. Electronic address: klaus.wanner@cup.uni-muenchen.de.

Eur J Med Chem ; 206: 112598, 2020 Nov 15.

Article em En | MEDLINE | ID: mdl-32896797

Assuntos

Proteínas da Membrana Plasmática de Transporte de GABA/metabolismo; Espectrometria de Massas; Neurônios/metabolismo; Oximas/química; Oximas/farmacologia; Avaliação Pré-Clínica de Medicamentos; Humanos; Ligantes; Oximas/metabolismo; Ligação Proteica

Palavras-chave

Affinity selection mass spectrometry; Combinatorial library; Hit identification; LC-MS; Library screening; MS Binding Assays

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Oximas / Espectrometria de Massas / Proteínas da Membrana Plasmática de Transporte de GABA / Neurônios Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Revista: Eur J Med Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Alemanha

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