Nonlinearities between inhibition and T-type calcium channel activity bidirectionally regulate thalamic oscillations.

Lu, Adam C; Lee, Christine Kyuyoung; Kleiman-Weiner, Max; Truong, Brian; Wang, Megan; Huguenard, John R; Beenhakker, Mark P

Lu, Adam C; Lee, Christine Kyuyoung; Kleiman-Weiner, Max; Truong, Brian; Wang, Megan; Huguenard, John R; Beenhakker, Mark P.

Afiliação

Lu AC; Department of Pharmacology, University of Virginia, Charlottesville, United States.
Lee CK; Department of Neurosurgery, Massachusetts General Hospital, Boston, United States.
Kleiman-Weiner M; Department of Psychology, Harvard University, Cambridge, United States.
Truong B; Department of Pharmacology, University of Virginia, Charlottesville, United States.
Wang M; Princeton Neuroscience Institute, Princeton University, Princeton, United States.
Huguenard JR; Department of Neurology, Stanford University, Palo Alto, United States.
Beenhakker MP; Department of Pharmacology, University of Virginia, Charlottesville, United States.

Elife ; 92020 09 09.

Article em En | MEDLINE | ID: mdl-32902384

Assuntos

Canais de Cálcio Tipo T/metabolismo; Modelos Neurológicos; Neurônios/fisiologia; Tálamo/fisiologia; Animais; Células Cultivadas; Proteínas da Membrana Plasmática de Transporte de GABA/metabolismo; Masculino; Ratos; Ratos Sprague-Dawley; Receptores de GABA-B/metabolismo; Convulsões/metabolismo

Palavras-chave

GABA transporter; GABAB receptor; T-type calcium channel; computational biology; network oscillations; neuroscience; rat; systems biology; thalamic networks; thalamocortical neuron

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tálamo / Canais de Cálcio Tipo T / Modelos Neurológicos / Neurônios Idioma: En Revista: Elife Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Estados Unidos

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