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Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.
Kwak, Hankyul; Koh, Wuhyun; Kim, Sangwoo; Song, Kiyeong; Shin, Jeong-Im; Lee, Jung Moo; Lee, Elliot H; Bae, Jin Young; Ha, Go Eun; Oh, Ju-Eun; Park, Yongmin Mason; Kim, Sunpil; Feng, Jiesi; Lee, Seung Eun; Choi, Ji Won; Kim, Ki Hun; Kim, Yoo Sung; Woo, Junsung; Lee, Dongsu; Son, Taehwang; Kwon, Soon Woo; Park, Ki Duk; Yoon, Bo-Eun; Lee, Jaeick; Li, Yulong; Lee, Hyunbeom; Bae, Yong Chul; Lee, C Justin; Cheong, Eunji.
Afiliação
  • Kwak H; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
  • Koh W; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science
  • Kim S; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
  • Song K; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
  • Shin JI; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea.
  • Lee JM; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, South Kor
  • Lee EH; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
  • Bae JY; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 41566, South Korea.
  • Ha GE; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
  • Oh JE; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
  • Park YM; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science
  • Kim S; Center for Cognition and Sociality, Institute for Basic Science, Daejeon 34126, South Korea; KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul 02841, South Korea.
  • Feng J; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China.
  • Lee SE; Virus Facility, Research Animal Resource Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
  • Choi JW; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, South Korea.
  • Kim KH; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
  • Kim YS; Department of Molecular Biology, College of Natural Science, Dankook University, Cheonan 31116, South Korea.
  • Woo J; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea.
  • Lee D; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea.
  • Son T; School of Electrical and Electronic Engineering, Yonsei University, Seoul 03722, South Korea.
  • Kwon SW; Radiation Medicine Clinical Research Division, Korea Institute of Radiological and Medical Sciences, Seoul, South Korea.
  • Park KD; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Convergence Research Center for Diagnosis, Treatment and Care System of Dementia, Korea Institute of Science and Technology, Seoul 02792, South Korea; KHU-KIST Departme
  • Yoon BE; Department of Molecular Biology, College of Natural Science, Dankook University, Cheonan 31116, South Korea.
  • Lee J; Doping Control Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
  • Li Y; State Key Laboratory of Membrane Biology, Peking University School of Life Sciences, Beijing 100871, China; Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China; PKU-IDG/McGovern Institute for Brain Research, Beijing 10087
  • Lee H; Molecular Recognition Research Center, Korea Institute of Science and Technology, Seoul 02792, South Korea.
  • Bae YC; Department of Anatomy and Neurobiology, School of Dentistry, Kyungpook National University, Daegu 41566, South Korea.
  • Lee CJ; Division of Bio-Medical Science &Technology, KIST School, Korea University of Science and Technology, Seoul 02792, South Korea; Center for Glia-Neuron Interaction, Korea Institute of Science and Technology, Seoul 02792, South Korea; Center for Cognition and Sociality, Institute for Basic Science
  • Cheong E; Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, South Korea; POSTECH Biotech Center, POSTECH, Pohang, South Korea. Electronic address: eunjicheong@yonsei.ac.kr.
Neuron ; 108(4): 691-706.e10, 2020 11 25.
Article em En | MEDLINE | ID: mdl-32905785
ABSTRACT
Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1. The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tálamo / Astrócitos / Percepção do Tato / Ácido gama-Aminobutírico / Inibição Neural Idioma: En Revista: Neuron Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Coréia do Sul
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tálamo / Astrócitos / Percepção do Tato / Ácido gama-Aminobutírico / Inibição Neural Idioma: En Revista: Neuron Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Coréia do Sul