Astrocytes Control Sensory Acuity via Tonic Inhibition in the Thalamus.
Neuron
; 108(4): 691-706.e10, 2020 11 25.
Article
em En
| MEDLINE
| ID: mdl-32905785
ABSTRACT
Sensory discrimination is essential for survival. However, how sensory information is finely controlled in the brain is not well defined. Here, we show that astrocytes control tactile acuity via tonic inhibition in the thalamus. Mechanistically, diamine oxidase (DAO) and the subsequent aldehyde dehydrogenase 1a1 (Aldh1a1) convert putrescine into GABA, which is released via Best1. The GABA from astrocytes inhibits synaptically evoked firing at the lemniscal synapses to fine-tune the dynamic range of the stimulation-response relationship, the precision of spike timing, and tactile discrimination. Our findings reveal a novel role of astrocytes in the control of sensory acuity through tonic GABA release.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Tálamo
/
Astrócitos
/
Percepção do Tato
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Ácido gama-Aminobutírico
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Inibição Neural
Idioma:
En
Revista:
Neuron
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Coréia do Sul