Supplementary medication in multiple sclerosis: Real-world experience and potential interference with neurofilament light chain measurement.
Mult Scler J Exp Transl Clin
; 6(3): 2055217320936318, 2020.
Article
em En
| MEDLINE
| ID: mdl-32922829
ABSTRACT
BACKGROUND:
As vitamins and dietary supplements are obtainable without prescription, treating physicians often ignore their intake by patients with multiple sclerosis (MS) and may therefore miss potential adverse effects and interactions.OBJECTIVE:
We aimed to assess the spectrum and intake frequency of supplementary medication in a cohort of MS patients and to analyse the effect of biotin intake on measurement of serum neurofilament light chain (sNfL), an emerging marker of disease activity.METHODS:
MS patients visiting our neurology outpatient clinic completed a questionnaire on their past or present use of vitamins or dietary supplements. In addition, the impact of two different doses of biotin (10 and 300 mg/day) on sNfL was studied in healthy volunteers.RESULTS:
Of 186 patients, 72.6% reported taking over-the-counter vitamins or dietary supplements currently or previously. Most frequently used was vitamin D (60.0%), followed by biotin. Female patients and patients with primary progressive MS tended to use supplements more frequently. Biotin intake did not interfere with sNfL measurement by single molecule array (Simoa).CONCLUSIONS:
The use of vitamins and dietary supplements is frequent among patients with MS. Thus, treating physicians should be aware of the pitfalls of supplementary treatment and educate their patients accordingly.
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Base de dados:
MEDLINE
Idioma:
En
Revista:
Mult Scler J Exp Transl Clin
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
Alemanha