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Vascular and Microvascular Dysfunction Induced by Microgravity and Its Analogs in Humans: Mechanisms and Countermeasures.
Navasiolava, Nastassia; Yuan, Ming; Murphy, Ronan; Robin, Adrien; Coupé, Mickael; Wang, Linjie; Alameddine, Asmaa; Gauquelin-Koch, Guillemette; Gharib, Claude; Li, Yinghui; Custaud, Marc-Antoine.
Afiliação
  • Navasiolava N; Clinical Research Center, CHU d'Angers, Angers, France.
  • Yuan M; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center (ACC), Beijing, China.
  • Murphy R; School of Health and Human Performance, Faculty of Science & Health, Dublin City University, Dublin, Ireland.
  • Robin A; Clinical Research Center, CHU d'Angers, Angers, France.
  • Coupé M; Mitovasc, UMR INSERM 1083-CNRS 6015, Université d'Angers, Angers, France.
  • Wang L; Mitovasc, UMR INSERM 1083-CNRS 6015, Université d'Angers, Angers, France.
  • Alameddine A; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center (ACC), Beijing, China.
  • Gauquelin-Koch G; Mitovasc, UMR INSERM 1083-CNRS 6015, Université d'Angers, Angers, France.
  • Gharib C; Centre National d'Études Spatiales (CNES), Paris, France.
  • Li Y; Institut NeuroMyoGène, Faculté de Médecine Lyon-Est, Université de Lyon, Lyon, France.
  • Custaud MA; State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center (ACC), Beijing, China.
Front Physiol ; 11: 952, 2020.
Article em En | MEDLINE | ID: mdl-32973543
Weightlessness and physical inactivity have deleterious cardiovascular effects. The space environment and its ground-based models offer conditions to study the cardiovascular effects of physical inactivity in the absence of other vascular risk factors, particularly at the macro- and microcirculatory levels. However, the mechanisms involved in vascular dysfunction and remodeling are not sufficiently studied in the context of weightlessness and its analogs including models of physical inactivity. Here, we summarize vascular and microvascular changes induced by space flight and observed in models of microgravity and physical inactivity and review the effects of prophylactic strategies (i.e., countermeasures) on vascular and microvascular function. We discuss physical (e.g., exercise, vibration, lower body negative pressure, and artificial gravity) and nutritional/pharmacological (e.g., caloric restriction, resveratrol, and other vegetal extracts) countermeasures. Currently, exercise countermeasure appears to be the most effective to protect vascular function. Although pharmacological countermeasures are not currently considered to fight vascular changes due to microgravity, nutritional countermeasures are very promising. Dietary supplements/natural health products, especially plant extracts, should be extensively studied. The best prophylactic strategy is likely a combination of countermeasures that are effective not only at the cardiovascular level but also for the organism as a whole, but this strategy remains to be determined.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Physiol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Front Physiol Ano de publicação: 2020 Tipo de documento: Article País de afiliação: França