Accessory olfactory bulb transplants correct hypogonadism in mutant mice.
Brain Res
; 415(1): 158-62, 1987 Jul 07.
Article
em En
| MEDLINE
| ID: mdl-3304529
ABSTRACT
Transplantation of normal fetal gonadotropin-releasing hormone (GnRH) neurons from the accessory olfactory bulb (AOB) to the third ventricle of GnRH-deficient adult mutant mice reverses the genetically determined reduction in pituitary hormones and poorly developed gonads. The transplanted heterotopic AOB neurons adapt their morphology and secretory functions to what is observed with preoptic GnRH neurons when transplanted into deficient mice and in the normal intact mature animal. This suggests the presence of median eminence trophic factors affecting the growth, terminal sprouting, and functional behavior of the transplanted neurons.
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Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
/
Ventrículos Cerebrais
/
Hormônios Liberadores de Hormônios Hipofisários
/
Hipogonadismo
Idioma:
En
Revista:
Brain Res
Ano de publicação:
1987
Tipo de documento:
Article