Yin-Yang 1 and HBx protein activate HBV transcription by mediating the spatial interaction of cccDNA minichromosome with cellular chromosome 19p13.11.

Shen, Congle; Feng, Xiaoyu; Mao, Tianhao; Yang, Danli; Zou, Jun; Zao, Xiaobin; Deng, Qiang; Chen, Xiangmei; Lu, Fengmin

Shen, Congle; Feng, Xiaoyu; Mao, Tianhao; Yang, Danli; Zou, Jun; Zao, Xiaobin; Deng, Qiang; Chen, Xiangmei; Lu, Fengmin.

Afiliação

Shen C; State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Feng X; State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Mao T; State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Yang D; State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Zou J; State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Zao X; State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Deng Q; Key Laboratory of Medical Molecular Virology (MOE & MOH), School of Basic Medical Sciences, Fudan University, Shanghai, People's Republic of China.
Chen X; State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.
Lu F; State Key Laboratory of Natural and Biomimetic Drugs, Department of Microbiology & Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, People's Republic of China.

Emerg Microbes Infect ; 9(1): 2455-2464, 2020 Dec.

Article em En | MEDLINE | ID: mdl-33084547

Assuntos

Carcinoma Hepatocelular/virologia; Cromossomos Humanos Par 19/metabolismo; DNA Viral/metabolismo; Vírus da Hepatite B/genética; Neoplasias Hepáticas/virologia; Transativadores/metabolismo; Proteínas Virais Reguladoras e Acessórias/metabolismo; Fator de Transcrição YY1/metabolismo; Carcinoma Hepatocelular/metabolismo; Linhagem Celular; Núcleo Celular/metabolismo; Núcleo Celular/virologia; Elementos Facilitadores Genéticos; Genoma Viral; Células Hep G2; Vírus da Hepatite B/metabolismo; Humanos; Neoplasias Hepáticas/metabolismo; Transcrição Gênica; Replicação Viral

Palavras-chave

HBV cccDNA; HBV transcription regulation; YY1; chromosome 19p13.11; spatial interaction

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Cromossomos Humanos Par 19 / DNA Viral / Transativadores / Vírus da Hepatite B / Carcinoma Hepatocelular / Fator de Transcrição YY1 / Proteínas Virais Reguladoras e Acessórias / Neoplasias Hepáticas Idioma: En Revista: Emerg Microbes Infect Ano de publicação: 2020 Tipo de documento: Article

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