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Neuroprotective schinortriterpenoids with diverse scaffolds from Schisandra henryi.
He, Tao-Bin; Yan, Bing-Chao; Hu, Kun; Li, Xiao-Nian; Sun, Han-Dong; Puno, Pema-Tenzin.
Afiliação
  • He TB; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049,
  • Yan BC; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China.
  • Hu K; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China.
  • Li XN; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China.
  • Sun HD; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China. Electronic address: hdsun@mail.kib.ac.cn.
  • Puno PT; State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, and Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming 650201, Yunnan, People's Republic of China. Electronic address: punopematenzin@mail.kib.ac.cn.
Bioorg Chem ; 105: 104353, 2020 12.
Article em En | MEDLINE | ID: mdl-33096311
Eleven undescribed schinortriterpenoids (SNTs) and one known analogue (12) were isolated from the stems and leaves of Schisandra henryi. Their diverse structures included preschisanartane (1), 18-norschiartane (2-5, 12), schiartane (6 and 7), and schisanartane (8-11) skeletons, which were elucidated by comprehensive NMR, MS, electronic circular dichroism analyses, single crystal X-ray diffraction and biogenetic considerations. 1 was the first case of preschisanartane-type SNT with six-membered lactone ring, and 2 was one of the most highly oxygenated 18-norschiartane SNTs. Three types of the highly oxygenated SNTs, 1, 4, 10 and 11, effectively prevent apoptosis induced by corticosterone in PC12 cells. In addition, 11 showed neurite outgrowth-promoting activity.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Extratos Vegetais / Caules de Planta / Folhas de Planta / Fármacos Neuroprotetores / Schisandra Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Extratos Vegetais / Caules de Planta / Folhas de Planta / Fármacos Neuroprotetores / Schisandra Idioma: En Revista: Bioorg Chem Ano de publicação: 2020 Tipo de documento: Article