Efficacy and safety of non-pharmacological interventions for irritable bowel syndrome in adults.
World J Gastroenterol
; 26(41): 6488-6509, 2020 Nov 07.
Article
em En
| MEDLINE
| ID: mdl-33244207
ABSTRACT
BACKGROUND:
Although nonpharmacological interventions (NPI) for irritable bowel syndrome (IBS) have been applied clinically, their relative efficacy and safety are poorly understood.AIM:
To compare and rank different NPI in the treatment of IBS.METHODS:
Five electronic databases were searched from their inception to January 12, 2020. Data of included publications were analyzed using network meta-analysis (NMA). Quality of endpoints were assessed by tools of the Cochrane Handbook and the GRADEpro software. Pooled relative risk or standardized mean difference with their corresponding 95% confidence intervals were used for statistical analysis. Surface under the cumulative ranking curve (SUCRA) probability value was conducted to rank the examined interventions. Sensitivity analysis was performed to verify the robustness of results and test the source of heterogeneity.RESULTS:
Forty randomized controlled trials with 4196 participants were included in this NMA. Compared with routine pharmacotherapies and placebo, acupuncture and cognitive behavioral therapy (CBT) had better efficacy in relieving IBS symptoms. Based on the SUCRA values, acupuncture ranked first in improving overall clinical efficacy and avoiding adverse effects. CBT ranked first in lowering the scores of IBS symptom severity scale, self-rating anxiety scale and self-rating depression scale.CONCLUSION:
This study confirmed the efficacy and safety of NPI for improving IBS symptoms, which to some extent recommended several interventions for clinical practice.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Medicinas Tradicionais:
Medicinas_tradicionales_de_asia
/
Medicina_china
Métodos Terapêuticos e Terapias MTCI:
Terapias_manuales
Assunto principal:
Terapia por Acupuntura
/
Síndrome do Intestino Irritável
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Etiology_studies
/
Systematic_reviews
Idioma:
En
Revista:
World J Gastroenterol
Ano de publicação:
2020
Tipo de documento:
Article
País de afiliação:
China