Evaluating and modulating TFEB in the control of autophagy: toward new treatments in CNS disorders.
Fundam Clin Pharmacol
; 35(3): 539-551, 2021 Jun.
Article
em En
| MEDLINE
| ID: mdl-33259088
ABSTRACT
TFEB is a mammalian transcription factor that binds directly to the CLEAR consensus sequence (5'-GTCACGTGAC-3') present in the regulatory regions of genes inducing autophagosome formation, autophagosome-lysosome fusion, hydrolase enzyme expression, and lysosomal exocytosis. By modulating these activities, TFEB coordinates on-demand control over each cell's degradation pathway. Thus, a nuclear signaling pathway regulates cellular energy metabolism through TFEB. Our growing understanding of the role of TFEB and CLEAR in the promotion of healthy clearance together with in vitro and in vivo preclinical findings in various animal models of disease supports the conclusion that the pharmacological activation of TFEB could clear toxic proteins to treat both rare and common forms of neurodegenerative disease.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Autofagia
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Doenças Neurodegenerativas
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Fatores de Transcrição de Zíper de Leucina e Hélice-Alça-Hélix Básicos
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Lisossomos
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Fundam Clin Pharmacol
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
França