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Epidemiology and Antimicrobial Susceptibility of Invasive Bacterial Infections in Children-A Population-Based Study From Norway.
Thaulow, Christian Magnus; Lindemann, Paul Christoffer; Klingenberg, Claus; Berild, Dag; Salvesen Blix, Hege; Myklebust, Tor Åge; Harthug, Stig.
Afiliação
  • Thaulow CM; From the Department of Clinical Science, University of Bergen.
  • Lindemann PC; Department of Pediatrics and Adolescence Medicine, Haukeland Universiy Hospital.
  • Klingenberg C; From the Department of Clinical Science, University of Bergen.
  • Berild D; Department of Microbiology, Haukeland University Hospital, Bergen, Norway.
  • Salvesen Blix H; Department of Health Sciences, UiT-The Arctic University of Norway.
  • Myklebust TÅ; Department of Pediatrics and Adolescence Medicine, University Hospital of North Norway, Tromsø, Norway.
  • Harthug S; Department of Clinical Medicine, University of Oslo.
Pediatr Infect Dis J ; 40(5): 403-410, 2021 05 01.
Article em En | MEDLINE | ID: mdl-33298760
OBJECTIVE: To describe epidemiology and antimicrobial susceptibility testing (AST) data of bacteria causing invasive infections in Norwegian children (0-18 years). METHODS: Population-based observational study using prospectively collected AST data from the Norwegian Surveillance System of Antimicrobial Resistance from 2013 to 2017. We included all clinically relevant bacterial isolates (blood and cerebrospinal fluid), and compared incidence of invasive infections and AST data in isolates from children and adults. RESULTS: We included 1173 isolates from children and 44,561 isolates from adults. Staphylococcus aureus accounted for 220/477 (46.2%, 95% CI: 41.6-50.7) of all isolates in schoolchildren (6-18 years). Compared with Streptococcus pneumonia isolates from adults (N = 2674), we observed higher nonsusceptibility rates to penicillin in isolates from children (N = 151), 11.9% versus 5.8%, P < 0.01; also higher resistance rates to erythromycin (11.3% vs. 4.9%, P < 0.01), clindamycin (9.3% vs. 3.6%, P < 0.001), and trimethoprim/sulfamethoxazole (17.9% vs. 6.4%, P < 0.001). Compared with Escherichia coli isolates in adults (N = 9073), we found lower rates of ESBL in isolates from children (N = 212), 2.4% versus 6.4%, P < 0.05. CONCLUSION: The study indicates the importance of microbiologic surveillance strategies in children and highlights the need for pediatric AST data. The high rates of nonsusceptibility to commonly used antibiotics among S. pneumoniae in children and the high burden of invasive S. aureus infections in schoolchildren calls for modifications of Norwegian guidelines.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Plantas_medicinales Assunto principal: Bactérias / Infecções Bacterianas / Resistência Microbiana a Medicamentos / Monitoramento Epidemiológico / Antibacterianos Tipo de estudo: Guideline / Observational_studies / Screening_studies País/Região como assunto: Europa Idioma: En Revista: Pediatr Infect Dis J Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Plantas_medicinales Assunto principal: Bactérias / Infecções Bacterianas / Resistência Microbiana a Medicamentos / Monitoramento Epidemiológico / Antibacterianos Tipo de estudo: Guideline / Observational_studies / Screening_studies País/Região como assunto: Europa Idioma: En Revista: Pediatr Infect Dis J Ano de publicação: 2021 Tipo de documento: Article