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Extracts of medicinal plants with natural deep eutectic solvents: enhanced antimicrobial activity and low genotoxicity.
Grozdanova, Tsvetinka; Trusheva, Boryana; Alipieva, Kalina; Popova, Milena; Dimitrova, Lyudmila; Najdenski, Hristo; Zaharieva, Maya M; Ilieva, Yana; Vasileva, Bela; Miloshev, George; Georgieva, Milena; Bankova, Vassya.
Afiliação
  • Grozdanova T; Institute of Organic Chemistry With Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 9, 1113, Sofia, Bulgaria.
  • Trusheva B; Institute of Organic Chemistry With Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 9, 1113, Sofia, Bulgaria.
  • Alipieva K; Institute of Organic Chemistry With Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 9, 1113, Sofia, Bulgaria.
  • Popova M; Institute of Organic Chemistry With Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 9, 1113, Sofia, Bulgaria.
  • Dimitrova L; The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 26, 1113, Sofia, Bulgaria.
  • Najdenski H; The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 26, 1113, Sofia, Bulgaria.
  • Zaharieva MM; The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 26, 1113, Sofia, Bulgaria.
  • Ilieva Y; The Stephan Angeloff Institute of Microbiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 26, 1113, Sofia, Bulgaria.
  • Vasileva B; Institute of Molecular Biology "Roumen Tsanev", Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113, Sofia, Bulgaria.
  • Miloshev G; Institute of Molecular Biology "Roumen Tsanev", Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113, Sofia, Bulgaria.
  • Georgieva M; Institute of Molecular Biology "Roumen Tsanev", Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 21, 1113, Sofia, Bulgaria.
  • Bankova V; Institute of Organic Chemistry With Centre of Phytochemistry, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 9, 1113, Sofia, Bulgaria. bankova@orgchm.bas.bg.
BMC Chem ; 14(1): 73, 2020 Dec 11.
Article em En | MEDLINE | ID: mdl-33308280
ABSTRACT
Natural deep eutectic solvents (NADES) are a new alternative to toxic organic solvents. Their constituents are primary metabolites, non-toxic, biocompatible and sustainable. In this study four selected NADES were applied for the extraction of two medicinal plants Sideritis scardica, and Plantago major as an alternative to water-alcohol mixtures, and the antimicrobial and genotoxic potential of the extracts were studied. The extraction efficiency was evaluated by measuring the extracted total phenolics, and total flavonoids. Best extraction results for total phenolics for the studied plants were obtained with choline chloride-glucose 52 plus 30% water; but surprisingly these extracts were inactive against all tested microorganisms. Extracts with citric acid-1,2-propanediol 14 and choline chloride-glycerol 12 showed good activity against S. pyogenes, E. coli, S. aureus, and C. albicans. Low genotoxicity and cytotoxicity were observed for all four NADES and the extracts with antimicrobial activity. Our results confirm the potential of NADESs for extraction of bioactive constituents of medicinal plants and further suggest that NADES can improve the effects of bioactive extracts. Further studies are needed to clarify the influence of the studied NADES on the bioactivity of dissolved substances, and the possibility to use such extracts in the pharmaceutical and food industry.
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Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Idioma: En Revista: BMC Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Bulgária
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Métodos Terapêuticos e Terapias MTCI: Terapias_biologicas Idioma: En Revista: BMC Chem Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Bulgária