Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity <i>via</i> inhibiting the deubiquitination activity of CSN5.

Liu, Yang; Liu, Xiaojia; Zhang, Na; Yin, Mingxiao; Dong, Jingwen; Zeng, Qingxuan; Mao, Genxiang; Song, Danqing; Liu, Lu; Deng, Hongbin

Berberine diminishes cancer cell PD-L1 expression and facilitates antitumor immunity via inhibiting the deubiquitination activity of CSN5.

Liu, Yang; Liu, Xiaojia; Zhang, Na; Yin, Mingxiao; Dong, Jingwen; Zeng, Qingxuan; Mao, Genxiang; Song, Danqing; Liu, Lu; Deng, Hongbin.

Afiliação

Liu Y; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Liu X; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Zhang N; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Yin M; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Dong J; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Zeng Q; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Mao G; Zhejiang Provincial Key Lab of Geriatrics, Department of Geriatrics, Zhejiang Hospital, Hangzhou 310013, China.
Song D; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Liu L; Qingdao Women and Children's Hospital, Qingdao University, Qingdao 266034, China.
Deng H; Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.

Acta Pharm Sin B ; 10(12): 2299-2312, 2020 Dec.

Article em En | MEDLINE | ID: mdl-33354502

Palavras-chave

AMC, 7-amino-4-methylcoumarin; BBR, berberine; Baf, bafilomycin; Berberine; CHX, cycloheximide; COP9 signalosome 5; CQ, chloroquine; CSN5, COP9 signalosome 5; IB, immunoblotting; ICB, immune checkpoint blockade; IFN-Î³, interferon-gamma; IHC, immunohistochemistry; Immune checkpoint blockade; MDSCs, myeloid-derived suppressor cells; NFAT, nuclear factor of activated T-cells; NSCLC, non-small cell lung cancer; PD-1, programmed cell death-1; PD-1/PD-L1 axis; PD-L1; PD-L1, programmed cell death ligand-1; SPR, surface plasmon resonance; T-cell immunity; TCM, traditional Chinese medicine; TILs, tumor-infiltrating lymphocytes; TNF-α, tumor necrosis factor-α; Tregs, regulatory T-lymphocytes; Ub, ubiquitin; qRT-PCR, quantitative real-time polymerase chain reaction

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Tipo de estudo: Prognostic_studies Idioma: En Revista: Acta Pharm Sin B Ano de publicação: 2020 Tipo de documento: Article País de afiliação: China

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