The efficacy of the anticancer 3-bromopyruvate is potentiated by antimycin and menadione by unbalancing mitochondrial ROS production and disposal in U118 glioblastoma cells.

Petricciuolo, Maya; Davidescu, Magdalena; Fettucciari, Katia; Gatticchi, Leonardo; Brancorsini, Stefano; Roberti, Rita; Corazzi, Lanfranco; Macchioni, Lara

Petricciuolo, Maya; Davidescu, Magdalena; Fettucciari, Katia; Gatticchi, Leonardo; Brancorsini, Stefano; Roberti, Rita; Corazzi, Lanfranco; Macchioni, Lara.

Afiliação

Petricciuolo M; Department of Experimental Medicine, University of Perugia, 06132, Perugia, Italy.
Davidescu M; Department of Experimental Medicine, University of Perugia, 06132, Perugia, Italy.
Fettucciari K; Department of Experimental Medicine, University of Perugia, 06132, Perugia, Italy.
Gatticchi L; Department of Experimental Medicine, University of Perugia, 06132, Perugia, Italy.
Brancorsini S; Department of Experimental Medicine, University of Perugia, 06132, Perugia, Italy.
Roberti R; Department of Experimental Medicine, University of Perugia, 06132, Perugia, Italy.
Corazzi L; Department of Experimental Medicine, University of Perugia, 06132, Perugia, Italy.
Macchioni L; Department of Experimental Medicine, University of Perugia, 06132, Perugia, Italy.

Heliyon ; 6(12): e05741, 2020 Dec.

Article em En | MEDLINE | ID: mdl-33364504

Palavras-chave

3-Bromopyruvate; Antimycin A; Biochemistry; Biological sciences; Cancer research; Cytochrome c; Glioblastoma cells; Menadione; Mitochondrial ROS; Oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Revista: Heliyon Ano de publicação: 2020 Tipo de documento: Article País de afiliação: Itália