Majonoside-R2 extracted from Vietnamese ginseng protects H9C2 cells against hypoxia/reoxygenation injury via modulating mitochondrial function and biogenesis.
Bioorg Med Chem Lett
; 36: 127814, 2021 03 15.
Article
em En
| MEDLINE
| ID: mdl-33486054
ABSTRACT
Vietnamese ginseng has a therapeutic effect on various diseases; however its bioactivity against cardiac hypoxia/reoxygenation (HR) injury remains unclear. In this study, we evaluated the protective roles of total saponin extract (TSE) and majonoside-R2 (MR2) targeting mitochondria in HR-induced rat cardiomyocyte H9C2 cells. The results showed that both TSE and MR2 effectively protected the cells from HR damage. Particularly, 9 µM of MR2 significantly increased the viability of HR-induced cells (p < 0.05). Interestingly, MR2 treatment markedly prevented the loss of mitochondrial membrane potential and cardiolipin content, and an increase in reactive oxygen species production in HR-treated H9C2 cells. Moreover, MR2 treatment altered the mRNA expression of genes involved in mitochondrial biogenesis under HR conditions. The present study documented for the first time the cardioprotective effects of MR2 against HR injury by maintaining mitochondrial function and modulating mitochondrial biogenesis.
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Texto completo:
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Base de dados:
MEDLINE
Medicinas Complementares:
Homeopatia
Assunto principal:
Traumatismo por Reperfusão Miocárdica
/
Hipóxia Celular
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Ginsenosídeos
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Panax
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Mitocôndrias
País/Região como assunto:
Asia
Idioma:
En
Revista:
Bioorg Med Chem Lett
Ano de publicação:
2021
Tipo de documento:
Article