[Pharmacokinetics of anthracycline antibiotics deposited by polymers]. / Izuchenie farmakokinetiki antratsiklinovykh antibiotikov deponirovannykh polimerami.

ABSTRACT

An increase of doxorubicin concentration in different organs and tissues and its decrease in the peripheral blood were observed when studying pharmacokinetics of this drug administered in the 10% solution of polyvinylpyrrolidone. A prolonged and stable release of carminomycin from glue composition MK-10-0 "carminacryl" confirms an expediency of alpha-cyanoacrylate use for deposition of anthracycline antibiotics with the aim of loco-regional chemotherapy.