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NTRK2 Fusion driven pediatric glioblastoma: Identification of oncogenic Drivers via integrative Genome and transcriptome profiling.
Britton, Heidi M; Levine, Adrian B; Shen, Yaoqing; Mungall, Karen; Serrano, Jonathan; Snuderl, Matija; Pleasance, Erin; Jones, Steven J M; Laskin, Janessa; Marra, Marco A; Rassekh, Shahrad R; Deyell, Rebecca; Yip, Stephen; Cheng, Sylvia; Dunham, Chris.
Afiliação
  • Britton HM; Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada.
  • Levine AB; Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada.
  • Shen Y; Canada's Michael Smith Genome Sciences Centre British Columbia Cancer Agency Vancouver Canada.
  • Mungall K; Canada's Michael Smith Genome Sciences Centre British Columbia Cancer Agency Vancouver Canada.
  • Serrano J; Department of Pathology New York University School of Medicine New York NY USA.
  • Snuderl M; Department of Pathology New York University School of Medicine New York NY USA.
  • Pleasance E; Canada's Michael Smith Genome Sciences Centre British Columbia Cancer Agency Vancouver Canada.
  • Jones SJM; Canada's Michael Smith Genome Sciences Centre British Columbia Cancer Agency Vancouver Canada.
  • Laskin J; Canada's Michael Smith Genome Sciences Centre British Columbia Cancer Agency Vancouver Canada.
  • Marra MA; Department of Medical Oncology British Columbia Cancer Agency Vancouver BC Canada.
  • Rassekh SR; Canada's Michael Smith Genome Sciences Centre British Columbia Cancer Agency Vancouver Canada.
  • Deyell R; Division of Pediatric Hematology/Oncology British Columbia Children's Hospital and the University of British Columbia Vancouver BC Canada.
  • Yip S; Division of Pediatric Hematology/Oncology British Columbia Children's Hospital and the University of British Columbia Vancouver BC Canada.
  • Cheng S; Department of Pathology and Laboratory Medicine University of British Columbia Vancouver Canada.
  • Dunham C; Division of Pediatric Hematology/Oncology British Columbia Children's Hospital and the University of British Columbia Vancouver BC Canada.
Clin Case Rep ; 9(3): 1472-1477, 2021 Mar.
Article em En | MEDLINE | ID: mdl-33768871
This is the first report of a NACC2-NTRK2 fusion in a histological glioblastoma. Oncogenomic analysis revealed this actionable fusion oncogene in a pediatric cerebellar glioblastoma, which would not have been identified through routine diagnostics, demonstrating the value of clinical genome profiling in cancer care.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Clin Case Rep Ano de publicação: 2021 Tipo de documento: Article
Texto completo
Adicionar na Minha BVS
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Prognostic_studies Idioma: En Revista: Clin Case Rep Ano de publicação: 2021 Tipo de documento: Article