Effects of Salvia miltiorrhiza Bunge extract and its single components on monosodium urate-induced pain in vivo and lipopolysaccharide-induced inflammation in vitro.
J Tradit Chin Med
; 41(2): 219-226, 2021 04.
Article
em En
| MEDLINE
| ID: mdl-33825401
ABSTRACT
OBJECTIVE:
To investigate the possible antinociceptive effects of Salvia (S.) miltiorrhiza Bunge and its single components in monosodium urate (MSU)-induced pain model in mice and lipopolysaccharide (LPS)-induced inflammation model in RAW264.7 cells.METHODS:
Pretreatment of S. miltiorrhiza Bunge extract (from 1 to 50 µg/mL) concentration-dependently attenuated LPS-induced nitric oxide (NO) release. The extract of S. miltiorrhiza Bunge (50 or 100 mg/kg) also caused reversals of decreased threshold for pain in the MSU-treated group as measured by Von-Frey test. Furthermore, we assessed the antinociceptive and anti-inflammatory properties of the active single components from S. miltiorrhiza Bunge such as 15, 16-dihydrotanshinone â tanshinone â ¡ cryptotanshinone, miltirone, tanshinone â ¡A, and salvianolic acid B. Some of them showed an anti-inflammatory effect in LPS-induced NO release model and an antinociceptive effect in MSU-treated pain model.RESULTS:
Our results suggest that S. miltiorrhiza Bunge extract may exert anti-inflammatory effect by reducing LPS-induced NO release and an antinociceptive property in MSU-treated pain model. Especially, tanshinoneâ ¡A, miltirone, cryptotanshinone, and 15,16-dihydrotanshinone â not only appear to be responsible for LPS-induced NO release induced by S. miltiorrhiza Bunge, but also in the production of S. miltiorrhiza Bunge extract-induced antinociception in MSU-treated pain model.CONCLUSION:
Therefore, the analgesic and anti-inflammatory property of S. miltiorrhiza Bunge indicate it as a therapeutic potential candidate for the treatment of pain and inflammation.Palavras-chave
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Dor
/
Extratos Vegetais
/
Salvia miltiorrhiza
/
Inflamação
/
Anti-Inflamatórios
Idioma:
En
Revista:
J Tradit Chin Med
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
Coréia do Sul