Plasma glycerophospholipid profile, erythrocyte n-3 PUFAs, and metabolic syndrome incidence: a prospective study in Chinese men and women.
Am J Clin Nutr
; 114(1): 143-153, 2021 07 01.
Article
em En
| MEDLINE
| ID: mdl-33829226
ABSTRACT
BACKGROUND:
Animal studies have highlighted critical roles of glycerophospholipid (GP) metabolism in various metabolic syndrome (MetS)-related features such as dyslipidemia, obesity, and insulin resistance. However, human prospective studies of associations between circulating GPs and risks of MetS are scarce.OBJECTIVES:
We aimed to investigate whether GPs are associated with incidence of MetS in a well-established cohort.METHODS:
A total of 1243 community-dwelling Chinese aged 50-70 y without MetS at baseline and followed up for 6 y were included in current analyses. A total of 145 plasma GPs were quantified by high-throughput targeted lipidomics. MetS was defined using the updated National Cholesterol Education Program Adult Treatment Panel III criteria for Asian Americans.RESULTS:
After 6 y, 429 participants developed MetS. Eleven GPs, especially those with long-chain polyunsaturated fatty acids (LCPUFAs) or very-long-chain polyunsaturated fatty acids (VLCPUFAs) at the sn-2 position, including 1 phosphatidylcholine (PC) [PC(180/226)], 9 phosphatidylethanolamines (PEs) [PE(160/226), PE(180/140), PE(180/181), PE(180/182), PE(180/203), PE(180/225), PE(180/226), PE(181/226), and PE(182/226)], and 1 phosphatidylserine (PS) [PS(180/180)], were positively associated with incident MetS (RRs 1.16-1.30 per SD change; Bonferroni-corrected P < 0.05). In network analysis, the strongest positive association for MetS incidence was evidenced in a module mainly composed of PEs containing C226 and PSs [RR 1.21; 95% CI 1.12, 1.31 per SD change; Bonferroni-corrected P < 0.05]. This association was more pronounced in participants with lower erythrocyte total n-3 PUFA concentrations [Bonferroni-corrected Pinter(P value for the interaction)< 0.05].CONCLUSIONS:
Elevated plasma concentrations of GPs, especially PEs with LCPUFAs or VLCPUFAs at the sn-2 position, are associated with higher risk of incident MetS. Future studies are merited to confirm our findings.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Ácidos Graxos Ômega-3
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Glicerofosfolipídeos
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Síndrome Metabólica
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Eritrócitos
Tipo de estudo:
Incidence_studies
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Observational_studies
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Risk_factors_studies
País/Região como assunto:
Asia
Idioma:
En
Revista:
Am J Clin Nutr
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China