Huoxin Pill inhibits isoproterenol-induced transdifferentiation and collagen synthesis in cardiac fibroblasts through the TGF-ß/Smads pathway.

Peng, Meizhong; Yang, Meiling; Lu, Yan; Lin, Shan; Gao, Huajian; Xie, Lingling; Huang, Bin; Chen, Daxin; Shen, Aling; Shen, Zhiqing; Peng, Jun; Chu, Jianfeng

Peng, Meizhong; Yang, Meiling; Lu, Yan; Lin, Shan; Gao, Huajian; Xie, Lingling; Huang, Bin; Chen, Daxin; Shen, Aling; Shen, Zhiqing; Peng, Jun; Chu, Jianfeng.

Afiliação

Peng M; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Yang M; The Third People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China.
Lu Y; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Lin S; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Gao H; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Xie L; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Huang B; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Chen D; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Shen A; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Shen Z; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Peng J; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ
Chu J; Academy of Integrative Medicine, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Chen Keji Academic Thought Inheritance Studio, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian Univ

J Ethnopharmacol ; 275: 114061, 2021 Jul 15.

Article em En | MEDLINE | ID: mdl-33892065

Assuntos

Cardiotônicos/farmacologia; Transdiferenciação Celular/efeitos dos fármacos; Colágeno/metabolismo; Medicamentos de Ervas Chinesas/farmacologia; Fibroblastos/efeitos dos fármacos; Proteínas Smad/antagonistas & inibidores; Fator de Crescimento Transformador beta/antagonistas & inibidores; Animais; Cardiotônicos/química; Cardiotônicos/uso terapêutico; Diferenciação Celular/efeitos dos fármacos; Movimento Celular/efeitos dos fármacos; Proliferação de Células/efeitos dos fármacos; Sobrevivência Celular/efeitos dos fármacos; Modelos Animais de Doenças; Medicamentos de Ervas Chinesas/química; Medicamentos de Ervas Chinesas/uso terapêutico; Fibroblastos/citologia; Fibroblastos/metabolismo; Fibrose/tratamento farmacológico; Fibrose/metabolismo; Coração/efeitos dos fármacos; Isoproterenol/toxicidade; Masculino; Miofibroblastos/efeitos dos fármacos; Cultura Primária de Células; Ratos Wistar; Transdução de Sinais/efeitos dos fármacos; Proteínas Smad/metabolismo; Comprimidos; Transcriptoma/efeitos dos fármacos; Fator de Crescimento Transformador beta/metabolismo

Palavras-chave

Cardiac fibroblasts; Cardiac fibrosis; Huoxin pill; Isoproterenol; TGF-ß/Smads pathway; Transdifferentiation

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Texto completo: 1 Base de dados: MEDLINE Medicinas Tradicionais: Medicinas_tradicionales_de_asia / Medicina_china Assunto principal: Medicamentos de Ervas Chinesas / Cardiotônicos / Fator de Crescimento Transformador beta / Colágeno / Proteínas Smad / Transdiferenciação Celular / Fibroblastos Tipo de estudo: Prognostic_studies Idioma: En Revista: J Ethnopharmacol Ano de publicação: 2021 Tipo de documento: Article

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