Preparation and characterization of selenium-rich polysaccharide from Phellinus igniarius and its effects on wound healing.
Carbohydr Polym
; 264: 117982, 2021 Jul 15.
Article
em En
| MEDLINE
| ID: mdl-33910711
ABSTRACT
The modified of polysaccharides show various bio-activities. In our work, Phellinus igniarius Selenium-enriched mycelias polysaccharides (PSeP) were prepared from Phellinus igniarius, and its antioxidant and anti-inflammatory effects on injured mice were evaluated. The selenium content and physical properties of polysaccharides were characterized by GC, HPGPC, and FT-IR analysis. The results showed that PSeP could reduce reactive oxygen species (ROS) levels, myeloperoxidase (MPO) activity as well as malondialdehyde (MDA) content. Meanwhile, it increased the enzyme activities of glutathione peroxidase (GSH-Px) and catalase (CAT). Finally, it showed obvious wound healing effects in vivo. Moreover, PSeP could clear the ROS without obvious cytotoxicity. PSeP could further improve its ability to clear ROS level to promote skin wound healing in mice three days in advance.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Selênio
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Cicatrização
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Ferimentos e Lesões
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Polissacarídeos Fúngicos
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Phellinus
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Antioxidantes
Idioma:
En
Revista:
Carbohydr Polym
Ano de publicação:
2021
Tipo de documento:
Article
País de afiliação:
China