Phosphocalcic metabolism and the role of vitamin D, vitamin K2, and nattokinase supplementation.
Crit Rev Food Sci Nutr
; 62(25): 7062-7071, 2022.
Article
em En
| MEDLINE
| ID: mdl-33966563
ABSTRACT
Calcium is involved in bone metabolism, regulation of nerve signaling, and release of neurotransmitters. Phosphorus is a structural component of ATP, participates in metabolic energy regulation, and ensures stability to biological membranes and cells. Vitamin D and vitamin K are important for intestinal absorption and renal excretion of calcium and phosphorus. Vitamin D plays a regulatory role in bone formation, carbohydrate metabolism, immune responses, and cardiovascular regulation. Research has linked vitamin D deficiency to the development of diabetes mellitus, hypertension, cancer, and osteoporosis. Vitamin K has been associated with a reduced risk of osteoporosis, cancer, and cardiovascular diseases (due to improved vascular elasticity). This review highlights the importance of vitamins D and K in the metabolism of calcium and phosphorus and explores various molecular mechanisms that help maintain the system's mineral homeostasis. Moreover, the paper reviews the enzyme nattokinase's role in thrombotic prevention due to its fibrinolytic activity.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Osteoporose
/
Vitamina D
Idioma:
En
Revista:
Crit Rev Food Sci Nutr
Ano de publicação:
2022
Tipo de documento:
Article
País de afiliação:
França