Treatment of a patient with a circadian sleep-wake disorder using a combination of melatonin and metoprolol.
J Clin Sleep Med
; 17(10): 2121-2124, 2021 10 01.
Article
em En
| MEDLINE
| ID: mdl-34032203
ABSTRACT
CITATION Circadian rhythm sleep-wake disorders result from the lack of synchronization between endogenous circadian rhythms and daily environmental or behavioral cycles. Current treatment of circadian rhythm sleep-wake disorders relies on strengthening normal zeitgebers, or temporal cues, through the combination of strict behavioral modification, controlled light exposure, and supplemental melatonin or melatonin receptor agonists. These therapies can be difficult to maintain and are supported with only limited clinical outcome data. The effectiveness of exogenous melatonin, in particular, may be reduced by the patient's continued production of endogenous melatonin with a temporal pattern that is not conducive to the desired sleep schedule. Here we describe the case of a single, sighted patient with a circadian rhythm sleep-wake disorder who benefited from the combined use of a beta blocker to suppress endogenous melatonin secretion along with the timed administration of exogenous melatonin. We suggest that the positive results obtained justify further study of this mechanism-guided approach. CITATION Gehrman PR, Anafi RC. Treatment of a patient with a circadian sleep-wake disorder using a combination of melatonin and metoprolol. J Clin Sleep Med. 2021;17(10)2121-2124.
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Base de dados:
MEDLINE
Assunto principal:
Transtornos do Sono-Vigília
/
Transtornos do Sono do Ritmo Circadiano
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Melatonina
Idioma:
En
Revista:
J Clin Sleep Med
Ano de publicação:
2021
Tipo de documento:
Article