Adaptation of bone and tendon to prolonged hindlimb suspension in rats.
J Appl Physiol (1985)
; 65(1): 373-6, 1988 Jul.
Article
em En
| MEDLINE
| ID: mdl-3403480
ABSTRACT
The rat hindlimb suspension model was used to ascertain the importance of ground reaction forces in maintaining bone and tendon homeostasis. Young female Sprague-Dawley rats were randomly assigned to either a suspended or a nonsuspended group. After 28 days, femur bones and patellar tendons were obtained for morphological and biochemical analyses. Prolonged suspension induced a significant change in the geometric configuration of the femur middiaphysis by increasing the minimum diameter (12%) without any significant alterations in cortical area, density, mineral, and collagen concentrations. Femur wet weight, length, DNA, and uronic acid concentrations of suspended animals were not significantly different from bones of nonsuspended rats. However, the collagen and proteoglycan concentrations in patellar tendons of suspended rats were 28% lower than the concentrations of matrix proteins in tissues obtained from nonsuspended animals. These data suggest that elimination of ground reaction forces induces alterations in tendon composition and femur diaphyseal shape by changing regional rates in bone remodeling and localized tendon strain. Therefore it appears that ground reaction forces are an important factor in the maintenance of cortical bone and patellar tendon homeostasis during weight-bearing conditions.
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Base de dados:
MEDLINE
Assunto principal:
Tendões
/
Osso e Ossos
/
Adaptação Fisiológica
/
Membro Posterior
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Appl Physiol (1985)
Ano de publicação:
1988
Tipo de documento:
Article