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Nanoparticles prepared from pterostilbene reduce blood glucose and improve diabetes complications.
Zhao, Xi; Shi, Anhua; Ma, Qiong; Yan, Xueyan; Bian, Ligong; Zhang, Pengyue; Wu, Junzi.
Afiliação
  • Zhao X; Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, School of Basic Medical, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, P.R. China.
  • Shi A; Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, School of Basic Medical, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, P.R. China.
  • Ma Q; Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, School of Basic Medical, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, P.R. China.
  • Yan X; College of Clinical Medical, Kunming Medical University, Kunming, Yunnan, 650500, PR China.
  • Bian L; College of Basic Medicine, Kunming Medical University, Kunming, Yunnan, 650500, PR China.
  • Zhang P; Key Laboratory of Acupuncture and Tuina for Treatment of Encephalopathy, College of Acupuncture, Tuina and Rehabilitation, Yunnan University of Traditional Chinese Medicine, Kunming, 650500, China. zpy19802000@163.com.
  • Wu J; Yunnan Provincial Key Laboratory of Molecular Biology for Sinomedicine, School of Basic Medical, Yunnan University of Chinese Medicine, Kunming, Yunnan, 650500, P.R. China. xnfz@ynutcm.edu.cn.
J Nanobiotechnology ; 19(1): 191, 2021 Jun 27.
Article em En | MEDLINE | ID: mdl-34176494
BACKGROUND: Diabetes complications are the leading cause of mortality in diabetic patients. The common complications are decline in antioxidant capacity and the onset of micro-inflammation syndrome. At present, glucose-responsive nanoparticles are widely used, as they can release insulin-loaded ultrafine particles intelligently and effectively reduce blood sugar. However, the toxicology of this method has not been fully elucidated. The plant extracts of pterostilbene (PTE) have a wide range of biological applications, such as antioxidation and inflammatory response improvement. Therefore, we have proposed new ideas for the cross application of plant extracts and biomaterials, especially as part of a hypoglycaemic nano-drug delivery system. RESULTS: Based on the PTE, we successfully synthesised poly(3-acrylamidophenyl boric acid-b-pterostilbene) (p[AAPBA-b-PTE]) nanoparticles (NPs). The NPs were round in shape and ranged between 150 and 250 nm in size. The NPs possessed good pH and glucose sensitivity. The entrapment efficiency (EE) of insulin-loaded NPs was approximately 56%, and the drug loading (LC) capacity was approximately 13%. The highest release of insulin was 70%, and the highest release of PTE was 85%. Meanwhile, the insulin could undergo self-regulation according to changes in the glucose concentration, thus achieving an effective, sustained release. Both in vivo and in vitro experiments showed that the NPs were safe and nontoxic. Under normal physiological conditions, NPs were completely degraded within 40 days. Fourteen days after mice were injected with p(AAPBA-b-PTE) NPs, there were no obvious abnormalities in the heart, liver, spleen, lung, or kidney. Moreover, NPs effectively reduced blood glucose, improved antioxidant capacity and reversed micro-inflammation in mice. CONCLUSIONS: p(AAPBA-b-PTE) NPs were successfully prepared using PTE as raw material and effectively reduced blood glucose, improved antioxidant capacity and reduced the inflammatory response. This novel preparation can enable new combinations of plant extracts and biomaterials to adiministered through NPs or other dosage forms in order to regulate and treat diseases.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estilbenos / Glicemia / Complicações do Diabetes / Nanopartículas Idioma: En Revista: J Nanobiotechnology Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estilbenos / Glicemia / Complicações do Diabetes / Nanopartículas Idioma: En Revista: J Nanobiotechnology Ano de publicação: 2021 Tipo de documento: Article